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Titolo:
ALK-POSITIVE LYMPHOMA - A SINGLE DISEASE WITH A BROAD-SPECTRUM OF MORPHOLOGY
Autore:
BENHARROCH D; MEGUERIANBEDOYAN Z; LAMANT L; AMIN C; BRUGIERES L; TERRIERLACOMBE MJ; HARALAMBIEVA E; PULFORD K; PILERI S; MORRIS SW; MASON DY; DELSOL G;
Indirizzi:
CHU PURPAN,ANAT PATHOL LAB,DEPT PATHOL,PL DR BAYLAC F-31059 TOULOUSE FRANCE CHU PURPAN,ANAT PATHOL LAB,DEPT PATHOL F-31059 TOULOUSE FRANCE CHU PURPAN,CNRS,CIGH TOULOUSE FRANCE INST GUSTAVE ROUSSY,DEPT PEDIAT ONCOL VILLEJUIF FRANCE JOHN RADCLIFFE HOSP,DEPT CELLULAR SCI,LRF IMMUNODIAGNOST UNIT OXFORD OX3 9DU ENGLAND UNIV BOLOGNA,SERV ANAT PATHOL BOLOGNA ITALY UNIV BOLOGNA,HEMATOPATHOL SECT BOLOGNA ITALY ST JUDE CHILDRENS HOSP,DEPT EXPT ONCOL MEMPHIS TN 38105
Titolo Testata:
Blood
fascicolo: 6, volume: 91, anno: 1998,
pagine: 2076 - 2084
SICI:
0006-4971(1998)91:6<2076:AL-ASD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE-CELL LYMPHOMA; NON-HODGKINS-LYMPHOMA; POLYMERASE CHAIN-REACTION; EPITHELIAL MEMBRANE ANTIGEN; KI-1 LYMPHOMA; T(2-5)(P23-Q35) TRANSLOCATION; CHROMOSOMAL TRANSLOCATION; MALIGNANT HISTIOCYTOSIS; GENE-PRODUCTS; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D. Benharroch et al., "ALK-POSITIVE LYMPHOMA - A SINGLE DISEASE WITH A BROAD-SPECTRUM OF MORPHOLOGY", Blood, 91(6), 1998, pp. 2076-2084

Abstract

The t(2;5)(p23;q35) translocation, associated with anaplastic large-cell lymphoma (ALCL), results in the expression of a chimeric NPM-ALK protein that can be detected by the ALK1 monoclonal antibody. This report describes the morphologic and phenotypic spectrum of 123 cases of lymphoma that all express ALK protein. The results provide strong evidence that the morphologic patterns of ALCL described in previous reports as representing possible subtypes of ALCL, eg, common type, lymphohistiocytic, or small cell patterns, are morphologic variants of the same disease entity. All of these morphologic patterns could be found within this series, and in some patients different subtypes coexisted in a single biopsy or were found in successive biopsies from a single patient. The link between these morphologic subtypes is further reinforced by the presence in all cases of a highly characteristic large cell, with an eccentric nucleus and an eosinophilic paranuclear region. We suggest that this cell can be considered as a major distinguishing feature of ALK-positive lymphomas. Another characteristic of these tumors was the perivascular pattern of neoplastic cell infiltration seen in asignificant number of cases. In addition to ALK protein, all tumors expressed epithelial membrane antigen and lacked CD15, features that may be of value in differentiating ALCL from Hodgkin's disease. In the majority of cases (84%), malignant cells showed both a cytoplasmic and nuclear staining for ALK1 and thus presumably carried the 2;5 translocation, but staining was restricted to the cytoplasm in a few cases, suggesting that translocations other than t(2;5) may induce expression of ALK protein. We conclude from this study that ALK-positive neoplasmsrepresent a distinct entity. Because their morphology is often neither anaplastic nor large cell, we suggest that they should henceforward he referred to as ALK lymphomas. (C) 1998 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:55:03