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Titolo:
HEPATIC SIDE-EFFECTS OF GROWTH-HORMONE TR EATMENT
Autore:
CESARETTI G; ROSSI A; FRANCHI G; SAGGESE G;
Indirizzi:
UNIV PISA,IST CLIN PEDIAT,CATTEDRA PEDIAT PREVENT & SOCIALE,VIA ROMA 35 I-56126 PISA ITALY UNIV PISA,IST CLIN PEDIAT,CATTEDRA PEDIAT PREVENT & SOCIALE I-56126 PISA ITALY
Titolo Testata:
Rivista italiana di pediatria
fascicolo: 5, volume: 20, anno: 1994,
pagine: 537 - 540
SICI:
0392-5161(1994)20:5<537:HSOGTE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ITA
Keywords:
GROWTH HORMONE; BILIRUBIN; TRANSAMINASES; GAMMA-GLUTAMYL-TRANSPEPTIDASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
G. Cesaretti et al., "HEPATIC SIDE-EFFECTS OF GROWTH-HORMONE TR EATMENT", Rivista italiana di pediatria, 20(5), 1994, pp. 537-540

Abstract

Blood levels of bilirubin, transaminases and gamma-glutamyltranspeptidase (gamma-GT) have been examined every six months in a group of 254 short subjects treated with growth hormone (GH) at the dose of 0.6-1 IU/Kg/week for a mean period of 4.4+/-1.1 (m+/-SD) years. On the basis of GH evaluation (two stimuli tests and examination over 24 hours or nocturnal 12 hours) and karyotype, they have been diagnosed as suffering from classical GH deficiency (deficient tests and spontaneous secretion, n = 26), from non-classical GH deficiency (normal tests and deficient spontaneous secretion, n = 198) and from Turner's syndrome (n = 30). The obtained results, considered overall, have not demonstrated any significant change in the values of examined parameters, which remained in the normal range over the entire period of treatment. Instead, when they have been considered individually, it has been possible to recognize one subject with a mild increase in bilirubin (1.5 mg/dl), which has returned to normal values after two months, and 7 cases with amild augmentation in transaminases and gamma-GT of a duration shorterthan three months. In no subject GH treatment has been interrupted. In conclusion, our data demonstrated that GH treatment does not cause any significant alteration of hepatic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 15:45:14