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Titolo:
DORSAL STRIATAL SIZE, SHAPE, AND METABOLIC-RATE IN NEVER-MEDICATED AND PREVIOUSLY MEDICATED SCHIZOPHRENICS PERFORMING A VERBAL-LEARNING TASK
Autore:
SHIHABUDDIN L; BUCHSBAUM MS; HAZLETT EA; HAZNEDAR MM; HARVEY PD; NEWMAN A; SCHNUR DB; SPIEGELCOHEN J; WEI TS; MACHAC J; KNESAUREK K; VALLABHAJOSULA S; BIREN MA; CIARAVOLO TM; LUUHSIA C;
Indirizzi:
CUNY MT SINAI SCH MED,DEPT PSYCHIAT,NEUROSCI PET LAB,BOX 1505,1 GUSTAVE L LEVY PL NEW YORK NY 10029 CUNY MT SINAI SCH MED,DEPT PSYCHIAT,NEUROSCI PET LAB NEW YORK NY 10029 MT SINAI HOSP,DEPT RADIOL,DIV NUCL MED NEW YORK NY 10029
Titolo Testata:
Archives of general psychiatry
fascicolo: 3, volume: 55, anno: 1998,
pagine: 235 - 243
SICI:
0003-990X(1998)55:3<235:DSSSAM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; REGIONAL BRAIN-FUNCTION; C-11 N-METHYLSPIPERONE; BASAL GANGLIA; FIRST-EPISODE; NEUROPSYCHOLOGICAL DEFICITS; HALOPERIDOL CHALLENGE; DOPAMINE-RECEPTORS; D-2 RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
L. Shihabuddin et al., "DORSAL STRIATAL SIZE, SHAPE, AND METABOLIC-RATE IN NEVER-MEDICATED AND PREVIOUSLY MEDICATED SCHIZOPHRENICS PERFORMING A VERBAL-LEARNING TASK", Archives of general psychiatry, 55(3), 1998, pp. 235-243

Abstract

Background: Magnetic resonance imaging and positron emission tomography were used to study the size and metabolic rate of the caudate and the putamen in 18 patients with schizophrenia (n=16) or schizo-affective disorder (n=2) and 24 age-and sex-matched control subjects. Methods:The patients were either never medicated (n=7) or drug free (n=11) for a median of 3 weeks. During uptake of fludeoxyglucose F 18, all patients performed a serial verbal learning test. Positron emission tomographic and magnetic resonance imaging scans were coregistered, and the caudate and the putamen were traced on the magnetic resonance image. Results: The striatum had a significantly lower relative metabolic ratein schizophrenics than in controls. Never-medicated patients had lower metabolic rates in the right putamen (ventral part of the dorsal striatum) than previously medicated patients. The caudate was significantly smaller in never-medicated patients than in controls and largest inpreviously medicated patients. Patients with higher relative metabolic rates in the putamen scored higher on the Abnormal Involuntary Movements Scale. Conclusions: The findings are consistent with reports of striatal enlargement in previously medicated patients and size increases after neuroleptic treatment. Never-medicated patients, in contrast, had ventral striatal structures that were smaller and less active thanthose observed in controls and previously medicated patients.

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Documento generato il 20/01/20 alle ore 15:57:54