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Titolo:
EFFECTS OF DL-3-N-BUTYLPHTHALIDE ON REGIONAL CEREBRAL BLOOD-FLOW IN RIGHT MIDDLE CEREBRAL-ARTERY OCCLUSION RATS
Autore:
YAN CH; FENG YP; ZHANG JT;
Indirizzi:
CHINESE ACAD MED SCI,PEKING UNION MED COLL,INST MAT MED BEIJING 100050 PEOPLES R CHINA CHINESE ACAD MED SCI,PEKING UNION MED COLL,INST MAT MED BEIJING 100050 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 2, volume: 19, anno: 1998,
pagine: 117 - 120
SICI:
0253-9756(1998)19:2<117:EODORC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIMODIPINE; TRIAL;
Keywords:
CEREBRAL ISCHEMIA; BOOD FLOW VELOCITY; CEREBRAL ARTERIES; CORPUS STRIATUM; DL-3-N-BUTYLPHTHALIDE; NIMODIPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Yan et al., "EFFECTS OF DL-3-N-BUTYLPHTHALIDE ON REGIONAL CEREBRAL BLOOD-FLOW IN RIGHT MIDDLE CEREBRAL-ARTERY OCCLUSION RATS", Zhongguo yaoli xuebao, 19(2), 1998, pp. 117-120

Abstract

AIM: To study the effect of dl-3-n-butylphthalide (NBP) on regional cerebral blood now (rCBF) in forcal cerebral ischemia rats. METHODS: Inchloral hydrate anesthetized rat, the proximal portion of right middle cerebral artery (RMCA) was occluded, and H-2 needle electrode was implanted in right striatum. rCBF was monitored in striatum using hydrogen clearance method. RESULTS: Ten min after RMCA occlusion (RMCAO), NBP (5, 10, 20 mg . kg(-1) ip) markedly increased rCBF to striatum (P < 0.01). When NBP was given ip 40 min after RMCAO, the increasing effecton rCBF was also observed (P < 0.05). However, when NBP was injected ip 60 min after RMCAO, the increasing effect of NBP on rCBF was not found. In NBP-pretreated (ip 40 min before RMCAO) group, rCBF in striatum measured at different time points of 30, 60, 90, 120, 150, and 180 min after RMCAO were increased by 97%, 107%, 136%, 211%, 173%, and 317%, compared with the percentages of vehicle The potency of the effect of Nim (0.5 mg . kg(-1) ip) was similar to that of NBP (10 mg . kg(-1)ip). CONCLUSION: NBP pre-treatment or posttreatment markedly enhanced the rCBF to striatum in RMCAO rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:34:39