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Titolo:
ENHANCEMENT OF (-)-STEPHOLIDINE ON PROTEIN-PHOSPHORYLATION OF A DOPAMINE-REGULATED AND CAMP-REGULATED PHOSPHOPROTEIN IN DENERVATED STRIATUMOF OXIDOPAMINE-LESIONED RATS
Autore:
GUO X; LIU J; ZOU LL; JIN J; WANG BC; JIN GZ;
Indirizzi:
CHINESE ACAD SCI,SHANGHAI INST MAT MED SHANGHAI 200031 PEOPLES R CHINA CHINESE ACAD SCI,SHANGHAI INST MAT MED SHANGHAI 200031 PEOPLES R CHINA STATE KEY LAB NUCL MED WUXI 214063 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 2, volume: 19, anno: 1998,
pagine: 100 - 103
SICI:
0253-9756(1998)19:2<100:EO(OPO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DARPP-32; BRAIN;
Keywords:
STEPHOLIDINE; PHOSPHOPROTEINS; PHOSPHORYLATION; DOPAMINE D-1 RECEPTORS; OXIDOPAMINE; CORPUS STRIATUM; SK-AND-F-38393; SCH-23390;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
X. Guo et al., "ENHANCEMENT OF (-)-STEPHOLIDINE ON PROTEIN-PHOSPHORYLATION OF A DOPAMINE-REGULATED AND CAMP-REGULATED PHOSPHOPROTEIN IN DENERVATED STRIATUMOF OXIDOPAMINE-LESIONED RATS", Zhongguo yaoli xuebao, 19(2), 1998, pp. 100-103

Abstract

AIM: To study effects of (-)-stepholidine (SPD) on the phosphorylation of a dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in the striatum of oxidopamine-lesioned rats. METHODS: The The mount of dephospho-DARPP-32 was measured by a back-phosphorylation assay. RESULTS: Inthe striatum of control rats, SPD per se had no effect on the phosphorylation of DARPP-32, but it antagonized the decrease by 28% of dephospho-DARPP-32 induced by the D-1 agonist SK&F-38393. In the denervated striatum of phosphorylation in the denervated striatum oxidopamine-lesioned rats, but it acts as a antagonist in normal striatum.oxidopamine-lesioned rats, SPD decreased the amount of dephospho-DARPP-32 by 44%. The effect of SPD was completely counteracted by the concomitant administration of the D-1 antagonist Sch-23390. CONCLUSION: SPD exhibits D-1 agonistic action of DARPP-32 phosphorylation in the denervated striatum oxidopamine-lesioned rats, but it acts as a antagonist in normal striatum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:52:03