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Titolo:
EFFECT OF CHOLESTEROL CONTENT IN DIET ON CAPILLARY-FLOW OF RAT ERYTHROCYTES - PART II - MECHANICAL-PROPERTIES
Autore:
PEDDADA RR; ABUGO OO; KELLY JF; ROTH GS; RIFKIND JM;
Indirizzi:
NIA,MOL & CELLULAR BIOL LAB,CTR GERONTOL RES,4940 EASTERN AVE BALTIMORE MD 21224 NIA,MOL & CELLULAR BIOL LAB,CTR GERONTOL RES BALTIMORE MD 21224 UNIV MARYLAND,SCH MED BALTIMORE MD 21201
Titolo Testata:
Clinical hemorheology and microcirculation
fascicolo: 6, volume: 17, anno: 1997,
pagine: 445 - 457
SICI:
1386-0291(1997)17:6<445:EOCCID>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-CELLS;
Keywords:
ERYTHROCYTE; DEFORMABILITY; HIGH CHOLESTEROL DIET; CAPILLARY FLOW; APPARENT VISCOSITY; FAHRAEUS EFFECT; INTRINSIC VISCOSITY; MEMBRANE SHEAR MODULUS OF ELASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Peddada et al., "EFFECT OF CHOLESTEROL CONTENT IN DIET ON CAPILLARY-FLOW OF RAT ERYTHROCYTES - PART II - MECHANICAL-PROPERTIES", Clinical hemorheology and microcirculation, 17(6), 1997, pp. 445-457

Abstract

Erythrocytes from male Fisher 344 rats on a high cholesterol diet (HC) exhibited a decreased ability to flow through capillaries when compared with those on a normal diet (control), a phenomenon which could not be explained by changes in geometric characteristics [1]. To explainthese results, changes in capillary-dependent rheological characteristics and intrinsic mechanical properties of red blood cells (RBC) due to diet were calculated. The hematocrit deficit in the capillary with respect to the reservoir was greater in the high cholesterol diet fed rats than in the control ones. This was attributed to an overall decrease in red cell deformability which, in turn, was related to an increase in the membrane shear viscosity, the cytoplasmic viscosity, the membrane shear modulus of elasticity, and the membrane bending rigidity. By an independent calculation, we determined that the shear modulus ofelasticity increased with a high cholesterol diet. The changes in both the capillary hematocrit deficit and the shear modulus of elasticitywith a high cholesterol diet were found to be statistically significant (p less than or equal to 0.05).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 23:53:27