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Titolo:
I-123 ALPHA-METHYL-L-TYROSINE SINGLE-PHOTON EMISSION TOMOGRAPHY FOR THE VISUALIZATION OF HEAD AND NECK SQUAMOUS-CELL CARCINOMAS
Autore:
FLAMEN P; BERNHEIM N; DERON P; CAVELIERS V; CHAVATTE K; FRANKEN PR; BOSSUYT A;
Indirizzi:
FREE UNIV BRUSSELS,ACAD HOSP,DEPT NUCL MED,LAARBEEKLAAN 101 B-1090 BRUSSELS BELGIUM FREE UNIV BRUSSELS,ACAD HOSP,DEPT OTORHINOLARYNGOL & HEAD & NECK SURGB-1090 BRUSSELS BELGIUM FREE UNIV BRUSSELS,ACAD HOSP,CYCLOTRON UNIT B-1090 BRUSSELS BELGIUM
Titolo Testata:
European journal of nuclear medicine
fascicolo: 2, volume: 25, anno: 1998,
pagine: 177 - 181
SICI:
0340-6997(1998)25:2<177:IASETF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE METASTASIS; EXTRACRANIAL HEAD; PET; TUMOR;
Keywords:
I-123 ALPHA-METHYL-L-TYROSINE; HEAD AND NECK CANCER; SINGLE-PHOTON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
P. Flamen et al., "I-123 ALPHA-METHYL-L-TYROSINE SINGLE-PHOTON EMISSION TOMOGRAPHY FOR THE VISUALIZATION OF HEAD AND NECK SQUAMOUS-CELL CARCINOMAS", European journal of nuclear medicine, 25(2), 1998, pp. 177-181

Abstract

The uptake of iodine-123 alpha-methyl-L-tyrosine (IMT) in the primarytumours and metastatic lymph nodes of squamous cell carcinoma of the head and neck was examined with single-photon emission tomography (SPET). Eleven patients with biopsy-proven carcinomas were studied prior to any therapeutic action. The evaluation of cervical lymph node involvement was based on the findings of physical examination, computed tomography and magnetic resonance imaging, and in six patients on the histological data relating to tissue samples obtained by fine-needle lymphnode aspiration or surgical intervention. SPET imaging was performed 10 min after the injection of 130-170 MBq IMT using a triple-head gamma camera equipped with medium-energy collimators. High-quality IMT SPET depicted the primary tumour in 10 of 11 patients (sensitivity: 91%). Tumours located in the larynx were visualized more clearly than thoselocated in the mouth or oropharynx. The mean tumour-to-background ratio was 2.35 (range: 1.6-3.1) for laryngeal rumours and 1.67 (range: 1.2-2.2) for mouth and oropharyngeal tumours. Metastatic cervical lymph nodes were involved to various degrees in 8 of the 11 patients. Among these eight patients there were 16 sites, nine of which were detected by IMT SPET (sensitivity: 56%), If the IMT SPET findings were recordedper side of the neck, the sensitivity was 64%, Five of the seven missed metastatic lymph nodes were smaller than 15 mm. The mean tumour-to-background ratio of the scintigraphically visualized lymph nodes was 1.81+/-0.51 (range: 1.39-2.77). Asymmetric physiological submandibular salivary gland IMT uptake led to false-positive lymph node assessment in three patients. This study indicates the potential use of IMT SPET as a metabolic imaging modality in patients with head and neck squamous cell carcinoma.

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Documento generato il 26/01/21 alle ore 04:28:13