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Titolo:
THEORETICAL-ANALYSIS OF MULTISTABILITY IN PYRAMIDAL NEURONS
Autore:
SVIRSKIS G; SVIRSKIENE N; GUTMAN A;
Indirizzi:
VYTAUTAS MAGNUS UNIV,DEPT ENVIRONM STUDIES KAUNAS LITHUANIA KAUNAS MED ACAD,BIOMED RES INST LT-3000 KAUNAS LITHUANIA
Titolo Testata:
Biofizika
fascicolo: 1, volume: 43, anno: 1998,
pagine: 87 - 91
SICI:
0006-3029(1998)43:1<87:TOMIPN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
RUS
Soggetto:
DENDRITIC MORPHOLOGY; VISUAL-CORTEX; RAT; CELLS;
Keywords:
PYRAMIDAL NEURONS; CALCIUM CHANNELS; MULTISTABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
G. Svirskis et al., "THEORETICAL-ANALYSIS OF MULTISTABILITY IN PYRAMIDAL NEURONS", Biofizika, 43(1), 1998, pp. 87-91

Abstract

The two-step switch off of the long duration Ca action potential was observed recently in neocortex pyramids [1]. The phenomenon was interpreted as an evidence of the N-type Ca-channel distribution in isolatedloci [1]. We demonstrate here that the two-step switch off can be imitated in the model with even channel distribution in a reconstructed pyramidal neuron as well. The first high plateau of the action potential corresponds to steady polarization of the whole membrane. The first switch off of the high plateau to the second low plateau corresponds to the switch off of the steady depolarization of the short basal dendrites. The steady depolarization of the long apical dendrite is more stable thus the switch off of the low plateau is a consequence of the apical dendrite repolarization. The model includes N-channel inactivation and a somatic shunt. The shunt may be artifactual, due to implement,or natural, due to postspike hyperpolarization. Recent experiments [2] have proved that the Ca-channels are located everywhere in the pyramidal cell.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:13:34