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Titolo:
LEVELS OF CIRCULATING ADHESION MOLECULES IN CONGESTIVE-HEART-FAILURE AND AFTER HEART-TRANSPLANTATION
Autore:
ANDREASSEN AK; NORDOY I; SIMONSEN S; UELAND T; MULLER F; FROLAND SS; GULLESTAD L; AUKRUST P;
Indirizzi:
UNIV OSLO,RIKSHOSP,DEPT MED A,CLIN IMMUNOL & INFECT DIS SECT N-0027 OSLO NORWAY UNIV OSLO,DEPT MED B,CARDIOL SECT,SECT CLIN IMMUNOL & INFECT DIS OSLONORWAY UNIV OSLO,DEPT MED A,INTERNAL MED RES INST OSLO NORWAY
Titolo Testata:
The American journal of cardiology
fascicolo: 5, volume: 81, anno: 1998,
pagine: 604 - 608
SICI:
0002-9149(1998)81:5<604:LOCAMI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; CARDIAC ALLOGRAFTS; P-SELECTIN; EXPRESSION; INFECTION; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Andreassen et al., "LEVELS OF CIRCULATING ADHESION MOLECULES IN CONGESTIVE-HEART-FAILURE AND AFTER HEART-TRANSPLANTATION", The American journal of cardiology, 81(5), 1998, pp. 604-608

Abstract

Recent reports suggest a role for immunologic and inflammatory processes in the pathogenesis of congestive heart failure (CHF) and accelerated coronary artery disease (CAD) after heart transplantation (HT), The interaction between endothelial cells, leukocytes, and platelets involving various adhesion molecules may be of particular importance, We therefore measured serum levels of soluble(s) vascular cell adhesion molecule-1 (VCAM-1), sP-selectin, and sE-selectin in 34 patients with severe CHF (23 with CAD and 11 with idiopathic dilated cardiomyopathy) and in 20 healthy controls, Twenty of the patients were followed with serial measurements of these circulating adhesion molecules (CAMs) forup to 2 years after HT, Levels of all 3 CAMs were significantly elevated in patients with CHF compared with controls irrespective of the etiology of heart failure, with particularly high concentrations of sVCAM-1, After HT, different patterns in CAMs were found over time, Whereas there was a normalization of sE-selectin levels after HT, concentrations of sVCAM-1 also declined, but without normalization, In contrast,sP-selectin levels were persistently elevated, with the highest concentrations at the end of the study period, The persistent elevation of sP-selectin and the lack of normalization of sVCAM-1 levels were associated with persistently raised serum levels of tumor necrosis factor-alpha, and these findings were not related to either acute episodes of allograft rejection or intercurrent infections, These results support the notion that immunologic and inflammatory processes are important features of CHF. Furthermore, the persistently elevated levels of CAMs and tumor necrosis factor-alpha found up to 2 years after HT may reflect a state of persistent immune activation in these patients, possiblyinvolved in the development of CAD after HT. (C) 1998 by Excerpta Medico, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:03:27