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Titolo:
PROSPECTIVE-STUDY OF SIMULTANEOUS ORTHOIODOHIPPURATE AND DIETHYLENETRIAMINEPENTAACETIC ACID CAPTOPRIL RENOGRAPHY
Autore:
BLAUFOX MD; FINE EJ; HELLER S; HURLEY J; JAGUST M; LI Y; MANN SJ; PICKERING TG; ZANZONICO P; ZHANG CG;
Indirizzi:
JACOBI MED CTR,DEPT NUCL MED,BN13,PELHAM PKWY & EASTCHESTER RD BRONX NY 10461 MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DEPT NUCL MED BRONX NY 10467 CORNELL UNIV,NEW YORK HOSP,DEPT MED NEW YORK NY 00000 CORNELL UNIV,NEW YORK HOSP,DEPT NUCL MED NEW YORK NY 00000 CORNELL UNIV,NEW YORK HOSP,DEPT RADIOL NEW YORK NY 00000
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 3, volume: 39, anno: 1998,
pagine: 522 - 528
SICI:
0161-5505(1998)39:3<522:POSOAD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-ARTERY STENOSIS; RENOVASCULAR HYPERTENSION; DIAGNOSIS; SCINTIGRAPHY; FLOW;
Keywords:
CAPTOPRIL RENOGRAPHY; RENOVASCULAR HYPERTENSION; RENAL INSUFFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Blaufox et al., "PROSPECTIVE-STUDY OF SIMULTANEOUS ORTHOIODOHIPPURATE AND DIETHYLENETRIAMINEPENTAACETIC ACID CAPTOPRIL RENOGRAPHY", The Journal of nuclear medicine, 39(3), 1998, pp. 522-528

Abstract

Captopril renography (CR) has been established in the past 10 yr as auseful diagnostic test for renovascular hypertension, However, directcomparison of tubular and glomerular tracers, quantitative criteria, comparison of quantitative and qualitative results and the reliabilityof the results in renal failure have not been described in a systematic, prospective fashion. Methods: Same-day baseline and CR using Tc-99m-labeled diethylenetriaminepentaacetic acid (DTPA) and [I-131]orthoiodohippurate (OIH) were simultaneously performed in two groups of hypertensive subjects, one with demographically defined essential hypertension (n = 43) and the other (n = 60) with a high prevalence of renovascular disease, defined with angiograms. Quantitative criteria for abnormal CR were derived from results among the subjects with essential hypertension. Qualitative analysis was performed using widely establishedcriteria. Results: There were no statistically significant differences between quantitative and qualitative accuracy, between OIH and DTPA or among quantitative parameters. The best accuracies for quantitativeCR were 56% with DTPA (n = 57) and 60% with OIH (n = 60), in both cases using the relative renal uptake parameter, Qualitative CR (n = 60) had accuracies of 43% (DTPA) and 50% (OIH), both hindered by 29 (DTPA)and 25 (OIH) abnormal but nondiagnostic studies, Two false-positive studies were detected, Twenty-seven of 29 nondiagnostic studies were associated with a glomerular filtration rate of <50 ml/min (n = 17), onesmall kidney (n = 17) and/or bilateral renal artery stenosis (n = 16). Supplemental measurement of in vitro stimulated plasma renin activity insignificantly (p > 0.10) and improved accuracies to 63% (DTPA) and70% (OIH), without introducing additional false-positive tests. Conclusion: Orthoiodohippurate and DTPA have comparable accuracy in prospective simultaneous evaluation of CR. False-positive studies are fewer than 5%, The accuracies of quantitative and qualitative criteria do notdiffer significantly but may be improved by supplemental use of the in vitro stimulated plasma renin activity. In individuals with renal insufficiency, small kidneys and/or bilateral renal artery disease, up to 48% of CR studies are abnormal but nondiagnostic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 04:59:46