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Titolo:
IMPAIRMENT OF BMIPP UPTAKE PRECEDES ABNORMALITIES IN OXYGEN AND GLUCOSE-METABOLISM IN HYPERTROPHIC CARDIOMYOPATHY
Autore:
TADAMURA E; KUDOH T; HATTORI N; INUBUSHI M; MAGATA Y; KONISHI J; MATSUMORI A; NOHARA R; SASAYAMA S; YOSHIBAYASHI M; TAMAKI N;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT NUCL MED & DIAGNOST IMAGING,SAKYO KU,54 SHOGOIN,KAWAHARA CHO KYOTO 60601 JAPAN KYOTO UNIV,FAC MED,DEPT NUCL MED KYOTO 60601 JAPAN KYOTO UNIV,FAC MED,DEPT INTERNAL MED,DIV 3 KYOTO 60601 JAPAN KYOTO UNIV,FAC MED,DEPT PEDIAT KYOTO 60601 JAPAN HOKKAIDO UNIV,SCH MED,DEPT NUCL MED SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 3, volume: 39, anno: 1998,
pagine: 390 - 396
SICI:
0161-5505(1998)39:3<390:IOBUPA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; BRANCHED FATTY-ACID; MYOCARDIAL BLOOD-FLOW; CARNITINE PALMITOYLTRANSFERASE-II; LEFT-VENTRICULAR HYPERTROPHY; SYMPTOMATIC PATIENTS; COMPUTED-TOMOGRAPHY; DOBUTAMINE INFUSION; WALL-MOTION; DEFICIENCY;
Keywords:
HYPERTROPHIC CARDIOMYOPATHY; BMIPP; PET; GLUCOSE METABOLISM; OXIDATIVE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
E. Tadamura et al., "IMPAIRMENT OF BMIPP UPTAKE PRECEDES ABNORMALITIES IN OXYGEN AND GLUCOSE-METABOLISM IN HYPERTROPHIC CARDIOMYOPATHY", The Journal of nuclear medicine, 39(3), 1998, pp. 390-396

Abstract

Impairment of fatty acid uptake is shown to precede myocardial perfusion abnormality using I-123-labeled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) in an experimental model of hypertrophic cardiomyopathy (HCM) and in human studies, We have recently demonstrated that abnormalities of both glucose and oxidative metabolism precede thereduction of blood flow in HCM, The main purposes of this study were to assess the frequency of abnormal findings in FDG uptake, BMIPP uptake and oxygen metabolism and to clarify the relationship among these metabolic parameters by using PET and SPECT. Methods: Twenty-eight subjects with HCM underwent FDG- and acetate-PET and thallium- and BMIPP-SPECT studies at rest, respectively. After correcting for partial volume effect, real percentages of FDG and BMIPP uptake were calculated. Inaddition, the clearance rate constant (K mono) of acetate was measured and normalized (%) to estimate the oxygen metabolism, Results: Therewere various metabolic abnormalities observed in patients with HCM, BMIPP uptake was often impaired without significant reduction of K monovalues or FDG uptake, Thus, abnormality of BMIPP uptake was more frequently observed than that for FDG uptake or K mono values (p < 0.0001,respectively). FDG uptake was relatively maintained even in the segments with reduced K mono values and reduced BMIPP uptake. Conclusion: HCM shows a variety of metabolic patterns; however, the results of our study suggest that reduction of BM IPP uptake appears to be the most sensitive indicator of metabolic abnormalities followed by reduction ofoxidative metabolism in patients with HCM.

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Documento generato il 09/04/20 alle ore 07:13:07