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Titolo:
CHURG-STRAUSS-SYNDROME - SERUM MARKERS OF LYMPHOCYTE-ACTIVATION AND ENDOTHELIAL DAMAGE
Autore:
SCHMITT WH; CSERNOK E; KOBAYASHI S; KLINKENBORG A; REINHOLDKELLER E; GROSS WL;
Indirizzi:
RHEUMAKLIN BAD BRAMSTEDT,OSKAR ALEXANDER STR 26 D-24576 BAD BRAMSTEDTGERMANY UNIV LUBECK BAD BRAMSTEDT GERMANY JUNTENDO UNIV TOKYO JAPAN
Titolo Testata:
Arthritis and rheumatism
fascicolo: 3, volume: 41, anno: 1998,
pagine: 445 - 452
SICI:
0004-3591(1998)41:3<445:C-SMOL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC HYPEREOSINOPHILIC-SYNDROME; SOLUBLE INTERLEUKIN-2 RECEPTOR; SYSTEMIC LUPUS-ERYTHEMATOSUS; CYTOPLASMIC ANTIBODY TITER; WEGENERS GRANULOMATOSIS; DISEASE-ACTIVITY; CELLS-INVITRO; CIRCULATING THROMBOMODULIN; ALLERGIC GRANULOMATOSIS; POLYARTERITIS-NODOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
W.H. Schmitt et al., "CHURG-STRAUSS-SYNDROME - SERUM MARKERS OF LYMPHOCYTE-ACTIVATION AND ENDOTHELIAL DAMAGE", Arthritis and rheumatism, 41(3), 1998, pp. 445-452

Abstract

Objective. To find serologic markers of disease activity in patients with Churg-Strauss syndrome (CSS) linked to possible pathogenetic mechanisms by studying endothelial cell damage (soluble thrombomodulin [sTM]) in relation to T cell and eosinophil activation markers (soluble interleukin-2 receptor [sIL-2R] and eosinophil cationic protein [ECP]),and the presence of autoantibodies (antineutrophil cytoplasmic antibodies [ANCA] and anti-endothelial cell antibodies [AECA]) during both active and inactive phases of disease. Methods. Sixteen consecutive patients who fulfilled the 1992 Chapel Hill definition of CSS were studied over a period of 4.5 +/- 3.9 years (mean +/- SD), ECP was detected by Columbo immunocapture (immunoCAP) assay, sIL-2R and sTM by enzyme-linked immunosorbent assay (ELISA), AECA by cell ELISA, and ANCA by indirect immunofluorescence and ELISA. Results. In patients with active disease, ECP (8.4 +/- 90 units/ml), sIL-2R (3,725 +/- 2,310 units/ml), and sTM levels (5.5 +/- 2.9 units/liter) were significantly elevated compared with those in remission, Levels of sIL-2R showed a close correlation with levels of sTM (r = 0.75, P < 0.05). Interestingly, during remission, sIL-2R levels remained elevated in 4 of 7 patients, althoughthe erythrocyte sedimentation rate, C-reactive protein level, and sTMlevel returned to the normal range (levels >1,000 units/ml were associated with relapse), ANCA were found in only 7 patients (4 had classicANCA, 3 had perinuclear ANCA), and AECA in 11 sera from 8 patients, In contrast to AECA, ANCA were associated with active disease. Conclusion, In its active state, CSS is associated with markedly increased levels of sIL-2R and ECP, indicating T cell and eosinophil activation, Elevated sTM is a sign of endothelial cell damage that can be closely linked to T cell activation, as indicated by increased sIL-2R levels.

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Documento generato il 30/11/20 alle ore 10:11:05