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Titolo:
ESTIMATION OF EFFECTS OF QUANTITATIVE TRAIT LOCI IN LARGE COMPLEX PEDIGREES
Autore:
MEUWISSEN THE; GODDARD ME;
Indirizzi:
DLO,INST ANIM SCI & HLTH,BOX 65 NL-8200 AB LELYSTAD NETHERLANDS UNIV NEW ENGLAND,ANIM GENET & BREEDING UNIT ARMIDALE NSW 2351 AUSTRALIA
Titolo Testata:
Genetics
fascicolo: 1, volume: 146, anno: 1997,
pagine: 409 - 416
SICI:
0016-6731(1997)146:1<409:EOEOQT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE ANALYSIS; MAJOR LOCUS; MODEL; LINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
T.H.E. Meuwissen e M.E. Goddard, "ESTIMATION OF EFFECTS OF QUANTITATIVE TRAIT LOCI IN LARGE COMPLEX PEDIGREES", Genetics, 146(1), 1997, pp. 409-416

Abstract

A method was derived to estimate effects of quantitative trait loci (QTL) using incomplete genotype information in large outbreeding populations with complex pedigrees. The method accounts for background genesby estimating polygenic effects. The basic equations used are very similar to the usual linear mixed model equations for polygenic models, and segregation analysis was used to estimate the probabilities of theQTL genotypes for each animal. Method R was used to estimate the polygenic heritability simultaneously with the QTL effects. Also, initial allele frequencies were estimated. The method was tested in a simulated data set of 10,000 animals evenly distributed over 10 generations, where 0, 400 or 10,000 animals were genotyped for a candidate gene. In the absence of selection, the bias of the QTL estimates was <2%. Selection biased the estimate of the Aa genotype slightly, when zero animals were genotyped. Estimates of the polygenic heritability were 0.251 and 0.257, in absence and presence of selection, respectively, while the simulated value was 0.25. Although not tested in this study, marker information could be accommodated by adjusting the transmission probabilities of the genotypes from parent to offspring according to the marker information. This renders a QTL mapping study in large multi-generation pedigrees possible.

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Documento generato il 22/09/20 alle ore 16:58:07