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Titolo:
THE EVOLUTION OF BACTERIAL TRANSFORMATION - SEX WITH POOR RELATIONS
Autore:
REDFIELD RJ; SCHRAG MR; DEAN AM;
Indirizzi:
FINCH UNIV HLTH SCI CHICAGO MED SCH,DEPT BIOL CHEM,3333 GREEN BAY RD N CHICAGO IL 60064 UNIV BRITISH COLUMBIA,DEPT ZOOL VANCOUVER BC V6T 1Z4 CANADA FINCH UNIV HLTH SCI CHICAGO MED SCH,DEPT BIOL CHEM N CHICAGO IL 60064 UNIV CHICAGO,DEPT MATH CHICAGO IL 60667
Titolo Testata:
Genetics
fascicolo: 1, volume: 146, anno: 1997,
pagine: 27 - 38
SICI:
0016-6731(1997)146:1<27:TEOBT->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTATION-SELECTION BALANCE; METABOLIC CONTROL-THEORY; DNA-REPAIR; DONOR DNA; INFLUENZAE; SYSTEMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Redfield et al., "THE EVOLUTION OF BACTERIAL TRANSFORMATION - SEX WITH POOR RELATIONS", Genetics, 146(1), 1997, pp. 27-38

Abstract

Bacteria are the only organisms known to actively take up DNA and recombine it into their genomes. While such natural transformation systems may provide many of the same benefits that sexual reproduction provides eukaryotes, there are important differences that critically alter the consequences, especially when recombination's main benefit is reducing the mutation load. Here, analytical and numerical methods are used to study the selection of transformation genes in populations undergoing deleterious mutation. Selection for transformability depends on the shape of the fitness function against mutation. Lf the fitness function is linear, then transformation would be selectively neutral were it not for the possibility that transforming cells may take up DNA that converts them into nontransformable cells. If the selection includesstrong positive (synergistic) epistasis, then transformation can be advantageous in spite of this risk. The effect of low quality DNA (fromselectively killed cells) on selection is then studied analytically and found to impose an additional cost. The limited data available for real bacterial populations suggest that the conditions necessary for the evolution of transformation are unlikely to be met, and thus that DNA uptake may have some function other than recombination of deleterious mutations.

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Documento generato il 26/09/20 alle ore 13:24:52