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Titolo:
POSSIBLE INVOLVEMENT OF VON-WILLEBRAND-FACTOR IN PANCREATIC GRAFT THROMBOSIS AFTER KIDNEY-PANCREAS TRANSPLANTATION - A RETROSPECTIVE STUDY
Autore:
KESSLER L; WIESEL ML; BOUDJEMA K; LUTUN E; MOULIN B; CAZENAVE JP; WOLF P; PINGET M;
Indirizzi:
HOP UNIV STRASBOURG,SERV ENDOCRINOL & MALAD NUTR,1 PL HOP F-67091 STRASBOURG FRANCE
Titolo Testata:
Clinical transplantation
fascicolo: 1, volume: 12, anno: 1998,
pagine: 35 - 42
SICI:
0902-0063(1998)12:1<35:PIOVIP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; RISK-FACTORS; CYCLOSPORINE;
Keywords:
VON WILLEBRAND FACTOR; GRAFT THROMBOSIS; PANCREAS TRANSPLANTATION; DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Kessler et al., "POSSIBLE INVOLVEMENT OF VON-WILLEBRAND-FACTOR IN PANCREATIC GRAFT THROMBOSIS AFTER KIDNEY-PANCREAS TRANSPLANTATION - A RETROSPECTIVE STUDY", Clinical transplantation, 12(1), 1998, pp. 35-42

Abstract

Early postoperative graft thrombosis remains the second cause of failure in pancreas transplantation. Thus, the aim of this study was to compare retrospectively coagulation and fibrinolysis in type I diabetic recipients of simultaneous kidney-pancreas transplants having or not experienced thrombosis of their pancreatic graft. From December 1990 toAugust 1996, 30 simultaneous kidney-pancreas transplants were performed in 30 uremic type I diabetic patients. Acute thrombosis of the pancreatic graft was observed among 6 patients (group A), whereas 24 did not develop thrombosis (group B) although 4 died from other causes. Thecontrol groups were composed of kidney transplant (group C) or haemodialysed (group D) non-diabetic patients, type I diabetics with HbA1C <8% (group E) or greater than or equal to 8% (group F) who were not inend-stage renal failure and kidney. transplant type I diabetic patients (group G). Beginning at least 6 months after transplantation, we analysed hemostatic factors (fibrinogen, thrombin, and prothrombin times), coagulation inhibitors (proteins C and S), fibrinolysis (plasminogen activator inhibitor) and endothelial cell abnormalities (Von Willebrand factor: VWf). Micro and macrovascular complications were evaluatedon a score ranging from 0 to 12. Hemostatic factors, coagulation inhibitors and fibrinolysis were similar in groups A and B whereas VWf differed significantly in group A (3.49 +/- 0.93 IU/ml) as compared to group B (2.04 +/- 0.92 IU/ml) (p < 0.05). VWf was also significantly increased in group A relative to the control groups C, D, E, F, and G. The score of vascular complications was increased in groups A and B and significantly higher in group A (9 +/- 0.81 vs. 6.07 +/- 1.75) (p < 0.01), while a correlation (r = 0.812, p > 0.05) was observed between VWf levels and the severity of vascular complications. These results point out the possible involvement of VWf in the pathogenesis of pancreatic vein thrombosis in kidney-pancreas transplantation.

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Documento generato il 25/11/20 alle ore 02:39:43