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Titolo:
MICROTUBULE DEPOLYMERIZATION IN UROMYCES-APPENDICULATUS BY 3 NEW ANTINEOPLASTIC DRUGS - COMBRETASTATIN A-4, DOLASTATIN-10 AND HALICHONDRIN-B
Autore:
ROBERSON RW; TUCKER B; PETTIT GR;
Indirizzi:
ARIZONA STATE UNIV,DEPT BOT,BOX 871601 TEMPE AZ 85287 ARIZONA STATE UNIV,CANC RES INST TEMPE AZ 85287
Titolo Testata:
Mycological research
, volume: 102, anno: 1998,
parte:, 3
pagine: 378 - 382
SICI:
0953-7562(1998)102:<378:MDIUB3>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBULIN; BINDING; MECHANISM; AGENTS; CYTOSKELETON; INHIBITION; NUCLEATION; SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Roberson et al., "MICROTUBULE DEPOLYMERIZATION IN UROMYCES-APPENDICULATUS BY 3 NEW ANTINEOPLASTIC DRUGS - COMBRETASTATIN A-4, DOLASTATIN-10 AND HALICHONDRIN-B", Mycological research, 102, 1998, pp. 378-382

Abstract

Three new antineoplastic natural products, combretastatin A-4, dolastatin 10 and halichondrin B, have been evaluated for their antimicrotubule activity in Uromyces appendiculatus urediniospore germlings using indirect immunofluorescence microscopy. In control germlings microtubules were abundant and mostly oriented parallel to the longitudinal axis of the cell. The microtubule cytoskeleton of germlings treated with 1.3 x 10(-5) M (10 mu g ml(-1)) dolastatin 10 and 4.5 x 10(-5) M (50 mu g ml(-1)) halichondrin B disrupted the microtubule cytoskeleton resulting in the near elimination of microtubule-associated fluorescence. Combretastatin A-4 was less effective, requiring a concentration of 3.2 x 10(-3) M (1.0 mg ml(-1)) to disrupt the microtubule cytoskeleton. These effective doses are consistent with previously examined antimicrotubule agents (e.g. nocodazole, griseofulvin, vincristine sulphate, demecolcine).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 03:28:12