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Titolo:
INHIBIN-B IS THE MAJOR FORM OF INHIBIN ACTIVIN FAMILY SECRETED BY GRANULOSA-CELL TUMORS/
Autore:
PETRAGLIA F; LUISI S; PAUTIER P; SABOURIN JC; REY R; LHOMME C; BIDART JM;
Indirizzi:
UNIV UDINE,DEPT SURG SCI,CHAIR OBSTET & GYNECOL I-33100 UDINE ITALY UNIV UDINE,DEPT SURG SCI,CHAIR OBSTET & GYNECOL I-33100 UDINE ITALY INST GUSTAVE ROUSSY,DEPT MED VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT ANAT PATHOL VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT BIOL CLIN VILLEJUIF FRANCE ECOLE NORMALE SUPER,UNITE RECH ENDOCRINOL DEV,INSERM,U493 MONTROUGE FRANCE
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 3, volume: 83, anno: 1998,
pagine: 1029 - 1032
SICI:
0021-972X(1998)83:3<1029:IITMFO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN-CANCER; ACTIVIN; MARKER; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
F. Petraglia et al., "INHIBIN-B IS THE MAJOR FORM OF INHIBIN ACTIVIN FAMILY SECRETED BY GRANULOSA-CELL TUMORS/", The Journal of clinical endocrinology and metabolism, 83(3), 1998, pp. 1029-1032

Abstract

Both experimental and clinical studies suggest that inhibin plays a critical role in the development of granulosa cell tumors (GCT), a subgroup of malignant ovarian tumors. Inhibin has been proposed as a biological marker for the followup of patients bearing these particular tumors. Hitherto, there is no general agreement on the molecular form(s) of the inhibin family that are secreted by malignant granulosa cells. Using specific and sensitive immunoassays for activin A and for inhibins A and B, we investigated the production of these molecules in patients with either an adult GCT (n=13) or an epithelial ovarian cancer (n=11). Results showed that serum activin A level was increased in all patients, independently of their clinical status (progressive disease or remission) in comparison to that observed in the healthy pre-and postmenopausal women. Most of the patients also presented a moderate increase in serum inhibin A level compared to that in controls. Only one of eight patients with a progressive granulosa cell tumor had a high value of serum inhibin A. In contrast, serum inhibin B was dramatically increased in eight of nine patients with a granulosa cell tumor and its level correlated with the clinical status of the patients. No correlation was found between the level of serum inhibin B and that of serumantimullerian hormone, a recently described specific and reliable marker for GCT. None of the patients with an epithelial ovarian cancer presented an increase of serum inhibin B. These observations demonstratethat inhibin B; is the major molecular form of the inhibin family proteins produced by malignant granulosa cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:42:19