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Titolo:
A REAPPRAISAL OF THE SKIN-SENSITIZING ACTIVITY OF 2,4-DINITROTHIOCYANOBENZENE
Autore:
DEARMAN RJ; CUMBERBATCH M; HILTON J; FIELDING I; BASKETTER DA; KIMBER I;
Indirizzi:
ZENECA,CENT TOXICOL LAB,ALDERLEY PK MACCLESFIELD SK10 4TJ CHESHIRE ENGLAND UNILEVER ENVIRONM SAFETY LAB SHARNBROOK MK44 1LQ BEDS ENGLAND
Titolo Testata:
Food and chemical toxicology
fascicolo: 2, volume: 35, anno: 1997,
pagine: 261 - 269
SICI:
0278-6915(1997)35:2<261:AROTSA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRAINING LYMPH-NODES; DELAYED-TYPE HYPERSENSITIVITY; CONTACT CHEMICAL ALLERGENS; SUPPRESSOR T-CELLS; DENDRITIC CELLS; IMMUNE-RESPONSES; INDUCTION-PHASE; LANGERHANS CELLS; GUINEA-PIG; TH1 CLONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Dearman et al., "A REAPPRAISAL OF THE SKIN-SENSITIZING ACTIVITY OF 2,4-DINITROTHIOCYANOBENZENE", Food and chemical toxicology, 35(2), 1997, pp. 261-269

Abstract

A debate continues regarding the immunological properties of 2,4-dinitrothiocyanobenzene (DNTB). In some investigations this chemical was shown not to cause skin sensitization when applied topically but to induce instead hyporesponsiveness or immunological tolerance. In other studies DNTB was found to cause skin sensitization, but not tolerance. However, this chemical continues to be used to discriminate between theproperties of skin sensitizing and non-sensitizing chemicals. This study demonstrates that topical exposure of mice to DNTB induces skin sensitization in mice and that this is associated with the accumulation of dendritic cells in draining lymph nodes and the stimulation of lymph node cell proliferation; the latter responses being of equivalent magnitude to those stimulated by 2,4-dinitrochlorobenzene (DNCB), a chemical known to cause contact sensitization. Moreover, exposure of mice to DNTB, as with exposure to DNCB, resulted in the development of a cytokine secretion pattern by draining lymph node cells (LNC) characteristic of contact allergens. Thus, DNTB and DNCB each induced the production by LNC of high levels of interferon-gamma, but little or no interleukin 4 or interleukin 10. Finally, DNTB was shown in the guinea pig maximization test to behave as an extreme skin sensitizer. These results confirm that DNTB should not be regarded as a universal tolerogen and that it possesses a significant potential to induce contact sensitization. The use of this chemical as a presumptive non-sensitizer and/or tolerogen for the evaluation of the selectivity of new predictive test methods for the identification of contact allergens is therefore considered to be inappropriate. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:20:52