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Titolo:
SUBSTANCE P-RELATED INHIBITORS OF MAST-CELL EXOCYTOSIS ACT ON G-PROTEINS OR ON THE CELL-SURFACE
Autore:
CHAHDI A; MOUSLI M; LANDRY Y;
Indirizzi:
UNIV LOUIS PASTEUR STRASBOURG 1,FAC PHARM,INSERM U425,LAB NEUROIMMUNOPHARMACOL,BP 24 F-67401 ILLKIRCH GRAFFENS FRANCE UNIV LOUIS PASTEUR STRASBOURG 1,FAC PHARM,INSERM U425,LAB NEUROIMMUNOPHARMACOL F-67401 ILLKIRCH GRAFFENS FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 341, anno: 1998,
pagine: 329 - 335
SICI:
0014-2999(1998)341:2-3<329:SPIOME>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING-PROTEINS; POSSIBLE INVOLVEMENT; HISTAMINE-SECRETION; DIRECT ACTIVATION; CHROMAFFIN CELLS; RECEPTOR; MASTOPARAN; ANTAGONISTS; MECHANISM; VENOM;
Keywords:
MAST CELL; G PROTEIN; [D-PRO(4),D-TRP(7,9,10)]SUBSTANCE P-(4-11); [P-GLU(4),D-TRP(7,9,10)]SUBSTANCE P-(5-11); MASTOPARAN; GTPASE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Chahdi et al., "SUBSTANCE P-RELATED INHIBITORS OF MAST-CELL EXOCYTOSIS ACT ON G-PROTEINS OR ON THE CELL-SURFACE", European journal of pharmacology, 341(2-3), 1998, pp. 329-335

Abstract

[p-Glu(5), D-Trp(7,9,10)]substance P-(5-11) inhibited mastoparan-stimulated GTPase activity in homogenized rat peritoneal mast cells and decreased histamine secretion induced by mastoparan from streptolysin O-permeabilized mast cells (IC50 of about 30 mu M), but not from intact cells. In contrast, [D-Pro(4), D-Trp(7,9,10)]substance P-(4-11) inhibited the secretion from intact cells (IC(5)0 of about 10 mu M) but had no effect on histamine secretion from permeabilized cells, suggesting that this peptide exerts its inhibitory effect on the plasma membrane,whereas [p-Glu(5), D-Trp(7,9,10)]substance P-(5-11) interacts with G proteins. Pretreatment of mast cells with neuraminidase led to an inhibition of the secretory response to mastoparan and related triggers. This response was restored following cell permeabilization, demonstrating the role of the cell surface on the entry of mastoparan and relatedtriggers and on their ability to reach G proteins sensitive to pertussis toxin and [p-Glu(5), D-Trp(7,9,10)]substance P-(5-11). (C) 1998 Elsevier Science B.V.

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Documento generato il 12/08/20 alle ore 18:12:30