Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TIME-COURSE OF CHRONIC DIAZEPAM EFFECTS ON THE AUDITORY-EVOKED POTENTIAL OF THE RAT
Autore:
JONGSMA MLA; VANRIJN CM; DEBRUIN EA; DIRKSEN R; COENEN AML;
Indirizzi:
UNIV NIJMEGEN,DEPT PSYCHOL,NICI,POB 9104 NL-6500 HE NIJMEGEN NETHERLANDS UNIV NIJMEGEN,NICI,DEPT EXPT ANESTHESIOL NL-6500 HE NIJMEGEN NETHERLANDS UNIV NIJMEGEN,NICI,DEPT COMPARAT & PHYSIOL PSYCHOL NL-6500 HE NIJMEGEN NETHERLANDS
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 341, anno: 1998,
pagine: 153 - 160
SICI:
0014-2999(1998)341:2-3<153:TOCDEO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; EEG; BENZODIAZEPINES; ANTICONVULSANT; BEHAVIOR; BRAIN; TOLERANCE; P300; PSYCHOMOTOR; ATTENTION;
Keywords:
TOLERANCE; AUDITORY EVOKED POTENTIAL; HABITUATION; ODDBALL PARADIGM; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M.L.A. Jongsma et al., "TIME-COURSE OF CHRONIC DIAZEPAM EFFECTS ON THE AUDITORY-EVOKED POTENTIAL OF THE RAT", European journal of pharmacology, 341(2-3), 1998, pp. 153-160

Abstract

The time course of chronic diazepam effects on auditory evoked potentials was studied in rats. Auditory evoked potentials were elicited by background and target tones in a passive oddball paradigm. Diazepam was administered by slow release implants to establish constant blood concentrations. Recordings were made during 21 days of treatment and 9 days after treatment ceased. Diazepam increased the amplitude of the P-40 component and decreased the amplitude of the P-72-P-102 components elicited by background tones. Diazepam increased the amplitude of the P-40-P-48 component and decreased that of the N-58 component elicited by target tones. These effects remained constant during treatment. Diazepam further decreased the amplitude of the P-102 component elicited by target tones. This effect became more distinct over time. No group differences were found 9 days after treatment. The constant drug effects on middle-latency components (P-40-P-48) might reflect diazepam-induced changes in sensory information processing. The decreased long-latency component (P-102) might reflect a diminished attention to, or discrimination of, target tones. The time course of this effect might reflect diazepam-enhanced habituation. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:30:30