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Titolo:
META-CHLOROPHENYLPIPERAZINE INDUCED CHANGES IN LOCOMOTOR-ACTIVITY AREMEDIATED BY 5-HT1 AS WELL AS 5-HT2C RECEPTORS IN MICE
Autore:
GLEASON SD; SHANNON HE;
Indirizzi:
ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,DC 0510 INDIANAPOLIS IN 46285
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 341, anno: 1998,
pagine: 135 - 138
SICI:
0014-2999(1998)341:2-3<135:MICILA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE STIMULUS PROPERTIES; RU-24969; AGONIST; ANTIDEPRESSANTS; MCPP;
Keywords:
M-CPP (1-(META-CHLORO)PHENYLPIPERAZINE)(I); 5-HT2C RECEPTOR; LY53857; 5-HTIB/ID RECEPTOR; GR 127935; 5-HT1A RECEPTOR; WAY 100,635; LOCOMOTOR ACTIVITY; (MOUSE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
S.D. Gleason e H.E. Shannon, "META-CHLOROPHENYLPIPERAZINE INDUCED CHANGES IN LOCOMOTOR-ACTIVITY AREMEDIATED BY 5-HT1 AS WELL AS 5-HT2C RECEPTORS IN MICE", European journal of pharmacology, 341(2-3), 1998, pp. 135-138

Abstract

1-(meta-chloro)phenylpiperazine (m-CPP) is a 5-HT receptor agonist which has been purported to be relatively selective for the 5-HT2C receptor. In particular, the hypolocomotion produced by m-CPP has been suggested to be mediated by 5-HT2C receptors. m-CPP binds with high affinity to 5-HT1 as well as 5-HT2 receptors, thus effects of m-CPP on locomotor activity may be due to the physiologic summation of the actions of m-CPP at 5-HT1 as well as 5-HT2 receptors. The present study investigated the effects of m-CPP alone and in the presence of the 5-HT2 receptor antagonist 6-methyl-1-(1-methyethyl)-ergoline-8 beta-carboxylic acid 2-hydroxy-1-methylpropyl ester maleate (LY53857), the 5-HT1A receptor antagonist zinyl]-ethyl}-N-(2pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY 100,635), and the 5-HT1B/1D receptor antagonist hyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-corboxydelic acid 4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]amide (GR 127935) on locomotor activity. Administration of m-CPP alone (0.3-10 mg/kg) produced a dose-related decrease in locomotor activity. The 5-HT1B/1D receptor antagonist GR 127935 (3.0 mg/kg) in combination with m-CPP produced a slight leftward shift of the dose-response curve of m-CPP. The 5-HT1A receptor antagonist WAY 100,635 (1.0 mg/kg) in combination with m-CPP did not alter the m-CPP dose-response curve. The non-selective 5-HT2 receptor antagonistLY53857 (1.0 mg/kg) in combination with m-CPP unmasked a hyperlocomotion produced by m-CPP. Furthermore, the hyperlocomotion produced by m-CPP in the presence of LY53857 (1.0 mg/kg) was blocked by both the 5-HT1B/1D receptor antagonist GR 127935 (3.0 mg/kg) and the 5-HT1A receptor antagonist WAY 100,635 (1.0 mg/kg). The present results demonstratethat the hyperlocomotion seen with the combination of m-CPP and LY53857 is mediated by 5-HT1 receptors. Taken together the data indicate that m-CPP affects locomotor activity by the physiologic summation of agonist activity at the 5-HT2C receptor as well as the 5-HT1 receptor family. (C) 1998 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:15:10