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Titolo:
CLOZAPINE THERAPY FOR OLDER VETERANS
Autore:
SAJATOVIC M; RAMIREZ LF; GARVER D; THOMPSON P; RIPPER G; LEHMANN LS;
Indirizzi:
CLEVELAND VET AFFAIRS MED CTR,10000 BRECKSVILLE RD BRECKSVILLE OH 44141 CASE WESTERN RESERVE UNIV,SCH MED CLEVELAND OH 44106 DALLAS VA MED CTR DALLAS TX 00000 UNIV TEXAS,SW MED SCH DALLAS TX 00000 VA CENT OFF,VA MENTAL HLTH STRATEG HEALTHCARE GRP WASHINGTON DC 00000 GEORGETOWN UNIV,SCH MED WASHINGTON DC 20057
Titolo Testata:
Psychiatric services
fascicolo: 3, volume: 49, anno: 1998,
pagine: 340 - 344
SICI:
1075-2730(1998)49:3<340:CTFOV>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-RESISTANT SCHIZOPHRENIA; ELDERLY PSYCHOTIC-PATIENTS; LONG-TERM TREATMENT; TARDIVE-DYSKINESIA; PARKINSONS-DISEASE; COST-EFFECTIVENESS; AGRANULOCYTOSIS; PATHOLOGY; SERVICES; SEVERITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M. Sajatovic et al., "CLOZAPINE THERAPY FOR OLDER VETERANS", Psychiatric services, 49(3), 1998, pp. 340-344

Abstract

Objective: The effectiveness of clozapine treatment in a treatment-refractory) sample of older adult veterans Kith primary psychosis was examined. Methods: Data were collected over a five-year period for patients age 55 and older who were given clozapine because of a history of treatment-refractory or treatment-intolerant psychosis. At initiation of clozapine therapy baseline demographic, clinical, and psychopathology data were collected. At baseline and quarterly, patients' psychopathology was rated with the Brief Psychiatric Rating Scale (BPRS), and involuntary movements were rated with the Abnormal Involuntary MovementScale (AIMS). Results: The 329 patients age 55 or older who received clozapine during the study. period represented 10 percent of all patients on clozapine therapy in the VA system. Of the 312 patients for whom demographic information was available, 294 were men and 18 were women. Overall, patients improved on clozapine therapy, although nide variation in drug response was observed, Complete BPRS and AIMS data were available for 97 patients, The 55- to 64-year-old group had a mean improvement in total BPRS score of 19.8 percent, with 42.6 percent showing more than a 20 percent improvement; those age 65 and older had a mean improvement of 5.7 percent, with 17.2 percent showing an improvementgreater than 20 percent. The 97 patients with complete AIMS data showed a mean improvement of 16.6 percent in total score. Conclusions: Clozapine is an important therapeutic agent for older adults with treatment-refractory psychosis. Patients between the ages of 55 and 64 may have a better response than those age 65 and older.

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Documento generato il 05/12/20 alle ore 01:40:09