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Titolo:
EXPRESSION OF RBM IN THE NUCLEI OF HUMAN GERM-CELLS IS DEPENDENT ON ACRITICAL REGION OF THE Y-CHROMOSOME LONG ARM
Autore:
ELLIOTT DJ; MILLAR MR; OGHENE K; ROSS A; KIESEWETTER F; PRYOR J; MCINTYRE M; HARGREAVE TB; SAUNDERS PTK; VOGT PH; CHANDLEY AC; COOKE H;
Indirizzi:
WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,CREWE RD EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND WESTERN GEN HOSP,DEPT PATHOL EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND WESTERN GEN HOSP,DEPT UROL EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND MRC,CTR REPROD BIOL EDINBURGH EH3 9EW MIDLOTHIAN SCOTLAND UNIV ERLANGEN NURNBERG,DEPT ANDROL D-91052 ERLANGEN GERMANY LISTER HOSP LONDON SW1W 8RH ENGLAND UNIV HEIDELBERG,INST HUMAN GENET,SECT HUMAN MOL GENET D-69120 HEIDELBERG GERMANY
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 8, volume: 94, anno: 1997,
pagine: 3848 - 3853
SICI:
0027-8424(1997)94:8<3848:EORITN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-BINDING PROTEIN; HUMAN SPERMATOGENESIS; HNRNP-G; GENE; LOCALIZATION; DELETION; AZF; MICRODELETIONS; DETERMINANTS; FERTILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Elliott et al., "EXPRESSION OF RBM IN THE NUCLEI OF HUMAN GERM-CELLS IS DEPENDENT ON ACRITICAL REGION OF THE Y-CHROMOSOME LONG ARM", Proceedings of the National Academy of Sciences of the United Statesof America, 94(8), 1997, pp. 3848-3853

Abstract

The association of abnormal spermatogenesis in men with Y chromosome deletions suggests that genes important for spermatogenesis have been removed from these individuals. Recently, genes encoding two putative RNA-binding proteins (RBM and DAZ/SPGY) have been mapped to two different regions of the human Y chromosome. Both of these genes encode proteins that contain a single RNA recognition motif and a (different) internally repeating sequence. Y-linked RBM homologues are found in all mammalian species. We have raised an antiserum to RBM and used it to show that RBM is a nuclear protein expressed in fetal, prepubertal, and adult male germ cells. The distribution of RBM protein in the adult correlates with the pattern of transcriptional activity in spermatogenesis, suggesting that RBM is involved in the nuclear metabolism of newlysynthesized RNA. RBM sequences are found on both arms of the Y chromosome making genotype-phenotype correlations difficult for this gene family. To address the location of the functional genes and the consequences of their deletion, we examined a panel of men with Y chromosome deletions and known testicular pathologies using this antiserum. This approach enabled us to map a region of the Y chromosome essential for RBM expression. In the absence of detectable RBM expression we see stages of germ cell development up to early meiosis, but not past this point into the haploid phase of spermatogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:24:22