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Titolo:
THE SOMATOSTATIN ANALOG, OCTREOTIDE, MODIFIES BOTH STEROIDOGENESIS AND IGFBP-1 SECRETION IN HUMAN LUTEINIZING GRANULOSA-CELLS
Autore:
MIMURO T; SMITH H; IWASHITA M; ILLINGWORTH PJ;
Indirizzi:
UNIV SYDNEY,WESTMEAD HOSP,DEPT REPROD ENDOCRINOL WESTMEAD NSW 2145 AUSTRALIA UNIV SYDNEY,WESTMEAD HOSP,DEPT REPROD ENDOCRINOL WESTMEAD NSW 2145 AUSTRALIA UNIV SYDNEY,WESTMEAD HOSP,DEPT ENDOCRINOL WESTMEAD NSW 2145 AUSTRALIA TOKYO WOMENS MED COLL,MATERNAL & PERINATAL CTR TOKYO 162 JAPAN
Titolo Testata:
Human reproduction
fascicolo: 1, volume: 13, anno: 1998,
pagine: 150 - 153
SICI:
0268-1161(1998)13:1<150:TSAOMB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BINDING PROTEIN-1; POLYCYSTIC-OVARY-SYNDROME; LUTEAL CELLS; FOLLICULAR-FLUID; GROWTH-FACTORS; HORMONE; SANDOSTATIN; INVITRO;
Keywords:
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-1; LUTEINIZED GRANULOSA CELLS; SOMATOSTATIN; STEROIDOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Mimuro et al., "THE SOMATOSTATIN ANALOG, OCTREOTIDE, MODIFIES BOTH STEROIDOGENESIS AND IGFBP-1 SECRETION IN HUMAN LUTEINIZING GRANULOSA-CELLS", Human reproduction, 13(1), 1998, pp. 150-153

Abstract

The effect of the somatostatin analogue octreotide on the secretion of progesterone and insulin-like growth factor binding protein-1 (IGFBP-1) from human granulosa-luteal cells was investigated, Octreotide (10(-11), 10(-10) and 10(-9) M) alone induced a significant decrease in progesterone secretion (maximum suppression 69 +/- 5% of control: P < 0.0001). In contrast, treatment with octreotide in combination with human chorionic gonadotrophin (HCG), at 1 IU/ml potentiated the stimulatory effect of HCG on progesterone secretion (HCG alone 201 +/- 3% of control: HCG + octreotide 10(-9) M 318 +/- 16%: P < 0.001). Treatment with octreotide increased the secretion of IGFBP-1 (maximum stimulation 254 +/- 25% of control: P < 0.01). No effect of HCG was seen on secretion of IGFBP-1. These findings raise the possibility that somatostatinmay have a modulatory role in regulating steroidogenesis by the humancorpus luteum, Further studies are required to establish the physiological significance of any such function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:29:52