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Titolo:
QUANTIFICATION BY MAGNETIC-RESONANCE SPECTROSCOPY OF METABOLITES IN SEMINAL PLASMA ABLE TO DIFFERENTIATE DIFFERENT FORMS OF AZOOSPERMIA
Autore:
HAMAMAH S; SEGUIN F; BUJAN L; BARTHELEMY C; MIEUSSET R; LANSAC J;
Indirizzi:
HOP BRETONNEAU,DEPT OBSTET GYNECOL,UNITE BIOL REPROD F-37044 TOURS FRANCE FAC MED TOURS,LAB BIOPH F-37044 TOURS FRANCE FAC MED TOURS,RMN,INSERM,U316 F-37044 TOURS FRANCE HOP GRAVE TOULOUSE,CTR STERILITE MASCULINE F-31052 TOULOUSE FRANCE
Titolo Testata:
Human reproduction
fascicolo: 1, volume: 13, anno: 1998,
pagine: 132 - 135
SICI:
0268-1161(1998)13:1<132:QBMSOM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; ALPHA-GLUCOSIDASE; MEN; FERTILIZATION; SPERMATOZOA; PREGNANCIES; EXTRACTION; FERTILITY; CARNITINE; MARKERS;
Keywords:
AZOOSPERMIA; HUMAN; MAGNETIC RESONANCE SPECTROSCOPY; SEMINAL PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Hamamah et al., "QUANTIFICATION BY MAGNETIC-RESONANCE SPECTROSCOPY OF METABOLITES IN SEMINAL PLASMA ABLE TO DIFFERENTIATE DIFFERENT FORMS OF AZOOSPERMIA", Human reproduction, 13(1), 1998, pp. 132-135

Abstract

The aim was to determine whether proton magnetic resonance spectroscopy (H-1-MRS) of metabolites such as glycerophosphorylcholine (GPC), choline, citrate and lactate in human seminal plasma can be used to differentiate (i) different azoospermic patients and (ii) different forms of spermatogenic failure including those who had undergone radiation therapy or chemotherapy, Semen samples were provided by men with obstructive azoospermia and spermatogenic failure who had serum follicle stimulating hormone (FSH) values within the normal range and either more or less than normal, Four prominent constituents of seminal plasma were identified by H-1-MRS: GPC, choline, citrate and lactate, The peak area ratios of choline/citrate as well as choline/lactate were significantly different (P < 0.01) between groups with spermatogenic failure and obstructive azoospermia. When the serum FSH values were normal in men with spermatogenic failure and obstructive azoospermia, a significant difference was found in the GPC/choline ratio (P < 0.001), When theFSH values were normal, the GPC/choline ratio appeared to be a very important parameter able to differentiate not only between cases of spermatogenic failure and obstructive azoospermia but also between different forms of spermatogenic failure, These results demonstrate the potential use of H-1-MRS on human seminal plasma in a new approach in the management of male infertility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:41:58