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Titolo:
ASSOCIATION BETWEEN AUTOANTIBODY MARKERS AND SUBTYPES OF DR4 AND DR4-DQ IN SWEDISH CHILDREN WITH INSULIN-DEPENDENT DIABETES REVEALS CLOSER ASSOCIATION OF TYROSINE PYROPHOSPHATASE AUTOIMMUNITY WITH DR4 THAN DQ8
Autore:
SANJEEVI CB; HAGOPIAN WA; LANDINOLSSON M; KOCKUM I; WOO W; PALMER JP; LERNMARK A; DAHLQUIST G;
Indirizzi:
KAROLINSKA HOSP,DEPT MOL MED S-10401 STOCKHOLM SWEDEN UNIV WASHINGTON,DEPT MED,RH WILLIAMS LAB SEATTLE WA 98195 UNIV LUND HOSP,DEPT MED S-22185 LUND SWEDEN UMEA UNIV,DEPT PEDIAT UMEA SWEDEN VET ADM MED CTR,DEPT MED SEATTLE WA 00000
Titolo Testata:
Tissue antigens
fascicolo: 3, volume: 51, anno: 1998,
pagine: 281 - 286
SICI:
0001-2815(1998)51:3<281:ABAMAS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; ISLET-CELL-ANTIBODIES; HLA-DQ; MOLECULAR-CLONING; MELLITUS; IDDM; RISK; DISEASE; GENES; SUSCEPTIBILITY;
Keywords:
HLA-DR; DQ; IDDM; GAD65 AUTOANTIBODIES; ICA; ICA512 AUTOANTIBODIES; INSULIN AUTOANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.B. Sanjeevi et al., "ASSOCIATION BETWEEN AUTOANTIBODY MARKERS AND SUBTYPES OF DR4 AND DR4-DQ IN SWEDISH CHILDREN WITH INSULIN-DEPENDENT DIABETES REVEALS CLOSER ASSOCIATION OF TYROSINE PYROPHOSPHATASE AUTOIMMUNITY WITH DR4 THAN DQ8", Tissue antigens, 51(3), 1998, pp. 281-286

Abstract

HLA DQA10301-DQB1*0302 (DQ8) and DQA1*0501-DQB1*0201 (DQ2) are positively and DQA10102-DQB1*0602 (DQ6) negatively associated With IDDM. In DQA10301-DQB1*0302 (DQ8)-positive patients, susceptibility is also mediated by DRB10401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDMand 367 controls in the age group of 0-15 years. We found that ICA512autoantibodies were associated primarily with DRB10401 and not with DQA10301-DQB1*0302 (DQ8). No such hier archy could be demonstrated for insulin autoantibodies, which were associated with both DQA10301-DQB10302 (DQ8) and DRB1*0401. GAD65 autoantibodies, known to be closelyassociated with DQA10501-DQB1*0201 (DQ2)-DRB1*0301 haplotype, also showed no preferential association with DQA10301-DQB1*0302 (DQ8) versus DRB104. These results suggest that the immune response to differentbeta-cell autoantigens may he mediated via HLA class II molecules from different loci. Design of the antigen-specific immune-intervention trials should take into account these HLA-DR and DQ subtype associations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:27:31