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Titolo:
IN-VITRO ANTIFUNGAL ACTIVITY OF SOME MANNICH-BASES OF CONJUGATED STYRYL KETONES
Autore:
MANAVATHU EK; VASHISHTHA SC; ALANGADEN GJ; DIMMOCK JR;
Indirizzi:
WAYNE STATE UNIV,DEPT INTERNAL MED,427 LANDE BLDG,550 E CANFIELD DETROIT MI 48201 WAYNE STATE UNIV,DEPT MED DETROIT MI 48201 UNIV SASKATCHEWAN,COLL PHARM & NUTR SASKATOON SK S7N 5C9 CANADA
Titolo Testata:
Canadian journal of microbiology
fascicolo: 1, volume: 44, anno: 1998,
pagine: 74 - 79
SICI:
0008-4166(1998)44:1<74:IAAOSM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANDIDA-ALBICANS; SUSCEPTIBILITY; RESISTANCE; AGENTS;
Keywords:
ANTIFUNGAL; STYRYL KETONES; CANDIDA ALBICAS; ASPERGILLUS FUMIGATUS; SUSCEPTIBILITY TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.K. Manavathu et al., "IN-VITRO ANTIFUNGAL ACTIVITY OF SOME MANNICH-BASES OF CONJUGATED STYRYL KETONES", Canadian journal of microbiology, 44(1), 1998, pp. 74-79

Abstract

Four Mannich bases of some conjugated styryl ketones IIa-IId were examined for antifungal activity. These compounds were designed as thiol-alkylators and had two centers for attack by cellular thiols. The mostpatent compounds IIa and IIb possessed hydrophobic, electron-attracting substituents in the aryl rings and in general had minimum inhibitory concentration (MIC) values of 0.2-25 mu M against a variety of fungi. None of the four compounds inhibited the growth of a number of bacteria (MIC > 100 mu M). The minimum fungicidal concentration (MFC) values for IIa and IIb were generally either similar or twofold higher thanthe MIC figures for fungi. Compound IIa demonstrated rapid, concentration-dependent inhibition of the growth of Candida albicans B311. The toxicity of IIa to normal human cells was much lower than the concentrations of this compound required to inhibit fungal growth. In summary,this study of four prototypic molecules has revealed that this class of compounds may have potential for further development as candidate antifungal agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:38:06