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Titolo:
PRIMARY GLAUCOMA TRIPLE PROCEDURE IN PATIENTS WITH PRIMARY OPEN-ANGLEGLAUCOMA - THE EFFECT OF MITOMYCIN-C IN PATIENTS WITH AND WITHOUT PROGNOSTIC FACTORS FOR FILTRATION FAILURE
Autore:
SHIN DH; REN JM; KIM C; SONG MS; YANG KJ; GLOVER KB;
Indirizzi:
WAYNE STATE UNIV,SCH MED,KRESGE EYE INST,4717 ST ANTOINE BLVD DETROITMI 48201
Titolo Testata:
American journal of ophthalmology
fascicolo: 3, volume: 125, anno: 1998,
pagine: 346 - 352
SICI:
0002-9394(1998)125:3<346:PGTPIP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FILTERING SURGERY; ADJUNCTIVE MITOMYCIN; CATARACT-EXTRACTION; FOLLOW-UP; TRABECULECTOMY; 5-FLUOROURACIL; HYPOTONY; FLUOROURACIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
D.H. Shin et al., "PRIMARY GLAUCOMA TRIPLE PROCEDURE IN PATIENTS WITH PRIMARY OPEN-ANGLEGLAUCOMA - THE EFFECT OF MITOMYCIN-C IN PATIENTS WITH AND WITHOUT PROGNOSTIC FACTORS FOR FILTRATION FAILURE", American journal of ophthalmology, 125(3), 1998, pp. 346-352

Abstract

PURPOSE: To investigate the effect of adjunctive mitomycin C on primary glaucoma triple procedure in patients with primary open angle glaucoma with and without one or more of the prognostic factors for filtration failure of primary glaucoma triple procedure. Those factors include being of African American race, having a preoperative intraocular pressure of 20 mm Hg or more on maximum tolerated medications, and beingon two or more medications preoperatively. METHODS: Study patients consisted of 197 consecutive patients with primary open-angle glaucoma who were randomly assigned to receive either no adjunctive mitomycin C (101 eyes of 101 patients) or to receive adjunctive subconjunctival mitomycin C (96 eyes of 96 patients) during the primary glaucoma triple procedure. Kaplan-Meier survival analysis comparisons were made between respective subgroups with and without prognostic indicators for filtration failures using a relatively stringent set of criteria for filtration success of primary glaucoma triple procedure. RESULTS: There wasno statistically significant (P = .117) difference in filtration success of primary glaucoma triple procedure between the control and mitomycin C groups. Adjunctive mitomycin C significantly (P < .05) improvedthe filtration outcome of the primary glaucoma triple procedure in the subgroups with each of the three prognostic factors for filtration failure of primary glaucoma triple procedure. On the other hand, in thesubgroups without the prognostic factors, adjunctive mitomycin C did not significantly (P > .05) change the filtration outcome of the primary glaucoma triple procedure. CONCLUSION: These findings establish thebasis for selective use of mitomycin C in patients with primary open-angle glaucoma undergoing primary glaucoma triple procedure. (C) 1998 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:56:21