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Titolo:
EFFECTS OF U-50,488H ON SCOPOLAMINE-INDUCED, MECAMYLAMINE-INDUCED ANDDIZOCILPINE-INDUCED LEARNING AND MEMORY IMPAIRMENT IN RATS
Autore:
HIRAMATSU M; MURASAWA H; NABESHIMA T; KAMEYAMA T;
Indirizzi:
MEIJO UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TENPAKU KU NAGOYA AICHI 468 JAPAN NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL & HOSP PHARM NAGOYA AICHI 466 JAPAN
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 3, volume: 284, anno: 1998,
pagine: 858 - 867
SICI:
0022-3565(1998)284:3<858:EOUOSM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIAL-ARM MAZE; RECEPTOR-MEDIATED INHIBITION; INDUCED DELAYED AMNESIA; PASSIVE-AVOIDANCE TASK; ACETYLCHOLINE-RELEASE; ALZHEIMERS-DISEASE; NICOTINIC RECEPTORS; DYNORPHIN A-(1-13); CHOLINERGIC INNERVATION; ALTERNATION PERFORMANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
M. Hiramatsu et al., "EFFECTS OF U-50,488H ON SCOPOLAMINE-INDUCED, MECAMYLAMINE-INDUCED ANDDIZOCILPINE-INDUCED LEARNING AND MEMORY IMPAIRMENT IN RATS", The Journal of pharmacology and experimental therapeutics, 284(3), 1998, pp. 858-867

Abstract

The role of kappa opioid receptor agonists in learning and memory is controversial. In the present study, the effects of U-50,488H on scopolamine-, mecamylamine- and dizocilpine-induced learning and memory impairments in rats were investigated. Scopolamine (3.3 mu mol/kg s.c.), a muscarinic cholinergic antagonist, and mecamylamine (40 mu mol/kg s.c.), a nicotinic cholinergic antagonist, significantly impaired learning and memory in rats in a step-through type passive avoidance test. Administration of U-50,488H (0.17 or 0.51 mu mol/kg s.c.) 25 min beforethe acquisition trial reversed the impairment of learning and memory induced by scopolamine and mecamylamine. Although low doses of scopolamine (0.17 mu mol/kg) and mecamylamine (12 mu mol/kg) had no effect, concurrent administration of both antagonists induced impairment of learning and memory. Scopolamine significantly increased acetylcholine release in the hippocampus as determined by in vivo brain microdialysis. On the other hand, mecamylamine significantly decreased acetylcholinerelease, U-50,488H completely blocked the decrease in acetylcholine release induced by mecamylamine, whereas it only partially blocked the increase of acetylcholine induced by scopolamine. On the other hand, an endogenous kappa opioid receptor agonist, dynorphin A (1-13), did not block the increase in acetylcholine release induced by scopolamine. The antagonistic effect of U-50,488H was abolished by pretreatment with nor-binaltorphimine (4.9 nmol/rat i.c.v.), a selective kappa opioid receptor antagonist. U-50,488H did not affect the impairment of learning and memory induced by the blockade of NMDA receptors by dizocilpine((+)-MK-801). These results suggest that U-50,488H reverses the impairment of learning and memory induced by the blockade of cholinergic transmission and abolishes the decrease of acetylcholine release inducedby mecamylamine via the kappa receptor-mediated opioid neuronal system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:40:13