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Titolo:
EFFECT OF PARENTERAL MEDIUM-CHAIN AND LONG-CHAIN TRIGLYCERIDES ON LYMPHOCYTES SUBPOPULATIONS AND FUNCTIONS IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME - A PROSPECTIVE-STUDY
Autore:
GELAS P; COTTE L; POITEVINLATER F; PICHARD C; LEVERVE X; BARNOUD D; LECLERCQ P; TOURAINEMOULIN F; TREPO C; BOULETREAU P;
Indirizzi:
HOP HOTEL DIEU,INTENS CARE UNIT,1 PL HOP F-69288 LYON 02 FRANCE DEPT HEPATOGASTROENTEROL LYON FRANCE DEPT IMMUNOL LYON FRANCE NUTR UNIT GENEVA SWITZERLAND NUTR UNIT GRENOBLE FRANCE CTR INFECT DIS GRENOBLE FRANCE
Titolo Testata:
JPEN. Journal of parenteral and enteral nutrition
fascicolo: 2, volume: 22, anno: 1998,
pagine: 67 - 71
SICI:
0148-6071(1998)22:2<67:EOPMAL>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-CARNITINE; INFECTED PATIENTS; LIPID EMULSIONS; HOST DEFENSE; OIL EMULSION; NUTRITION; CELLS; AIDS; MONONUCLEAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P. Gelas et al., "EFFECT OF PARENTERAL MEDIUM-CHAIN AND LONG-CHAIN TRIGLYCERIDES ON LYMPHOCYTES SUBPOPULATIONS AND FUNCTIONS IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME - A PROSPECTIVE-STUDY", JPEN. Journal of parenteral and enteral nutrition, 22(2), 1998, pp. 67-71

Abstract

Background: Total parenteral nutrition (TPN) may offer significant clinical benefit in malnourished patients with acquired immunodeficiencysyndrome (AIDS). However, the immunologic effect of parenteral lipidsremains unknown in these severely immunodepressed patients. Methods: We undertook a prospective randomized double-blind multicenter study comparing the effects of two IV lipid emulsions used during TPN: long-chain triglycerides (LCT) or balanced emulsion of long-and medium-chaintriglycerides (LCT/MCT). Thirty-three AIDS patients requiring TPN forwasting and reduced oral intake were allocated randomly to receive a ternary TPN mixture consisting of 1.5 g/kg/d proteins, 18 kcal/kg/d lipids, and 12 kcal/g/d carbohydrates for 6 days. The following tests were pet-formed at days 0 and 7: inununoglobulins, complement fractions,lymphocyte subpopulations count, and lymphocyte proliferation with mitogens. Results: Patients were all severely malnourished (weight loss:-14.0 +/- 1.3 kg). No clinical or biological differences were observed between the groups at baseline. At day 7, both groups reported a significant increase in weight. Patients in the LCT group exhibited a significant decrease in phytohemagglutinin A response (p = .04) compared with baseline. Patients in the LCT/MCT group exhibited a lower level of IgM (P = .03) and a significant increase in C3 fraction (P = .03) compared with baseline. They also showed a tendency to have a higher CD4/CD8 lymphocyte ratio (p = .01), whereas other immunological parameters remained unchanged. Conclusions: Parenteral ternary mixture containing LCT or LCT/MCT are clinically well tolerated in AIDS patients over 6 days. With 2 g/kg/d of lipids, LCT seems to induce significant abnormalities in lymphocyte function. Such abnormalities are not observed with LCT/MCT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:49:12