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Titolo:
VASOREACTIVITY IN PRE-MENOPAUSAL AND POSTMENOPAUSAL WOMEN - EVALUATION BY PHARMACODYNAMIC MODELING
Autore:
CHING MI; SUNG BH; FORREST A; WILSON MF; IZZO JL;
Indirizzi:
MILLARD FILLMORE HOSP,CLIN PHARMACOKINET LAB,3 GATES CIRCLE BUFFALO NY 14209 MILLARD FILLMORE HOSP,CLIN PHARMACOKINET LAB BUFFALO NY 14209 SUNY BUFFALO,DEPT MED BUFFALO NY 14260 SUNY BUFFALO,CLIN PHARMACOKINET LAB BUFFALO NY 14260
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 2, volume: 38, anno: 1998,
pagine: 151 - 159
SICI:
0091-2700(1998)38:2<151:VIPAPW>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-DISEASE; CHRONIC HYPERINSULINEMIA; INSULIN RESISTANCE; CORONARY-ARTERY; BLOOD-PRESSURE; HYPERTENSION; FRAMINGHAM; RELAXATION; MENOPAUSE; ESTROGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Ching et al., "VASOREACTIVITY IN PRE-MENOPAUSAL AND POSTMENOPAUSAL WOMEN - EVALUATION BY PHARMACODYNAMIC MODELING", Journal of clinical pharmacology, 38(2), 1998, pp. 151-159

Abstract

Postmenopausal women experience an increase in cardiovascular mortality and morbidity compared with their premenopausal counterparts. This study was undertaken to develop a pharmacodynamic model to determine whether vascular reactivity in postmenopausal women differed from that in premenopausal women. Eleven subjects in each group were recruited. Graded doses of norepinephrine and insulin were infused via the dorsalhand vein. Venous diameter was measured by ultrasound. Dosage and venous diameter were fit to a Hill-type pharmacodynamic; model in which norepinephrine acts as a vasoconstrictor and insulin counteracts varying fractions of norepinephrine constriction. Fitted pharmacodynamic parameters for norepinephrine did not differ uniformly between groups, but at norepinephrine infusion rates between 14 and 46 ng/mL, postmenopausal women demonstrated increased norepinephrine-induced vasoconstriction. Also, the modeled maximal response to insulin (Emax(i)) was greater in premenopausal women. By stepwise linear regression, maximal response to insulin was found to be related to menopausal status and diastolic blood pressure. Postmenopausal women showed differences in vasoreactivity that may have important implications in the pathogenesis of hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:42:40