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Titolo:
RECOGNITION OF STRESS-INDUCED MHC MOLECULES BY INTESTINAL EPITHELIAL GAMMA-DELTA T-CELLS
Autore:
GROH V; STEINLE A; BAUER S; SPIES T;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,DIV CLIN RES,1100 FAIRVIEW AVE N SEATTLEWA 98109
Titolo Testata:
Science
fascicolo: 5357, volume: 279, anno: 1998,
pagine: 1737 - 1740
SICI:
0036-8075(1998)279:5357<1737:ROSMMB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-I MOLECULES; HUMAN INTRAEPITHELIAL LYMPHOCYTES; MONOCLONAL-ANTIBODY; NONPEPTIDE ANTIGENS; PERIPHERAL-BLOOD; RECEPTOR; GENE; EXPRESSION; DIVERSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
V. Groh et al., "RECOGNITION OF STRESS-INDUCED MHC MOLECULES BY INTESTINAL EPITHELIAL GAMMA-DELTA T-CELLS", Science, 279(5357), 1998, pp. 1737-1740

Abstract

T cells with variable region V(delta)1 gamma delta T cell receptors (TCRs) are distributed throughout the human intestinal epithelium and may function as sentinels that respond to self antigens. The expressionof a major histocompatibility complex (MHC) class I-related molecule,MICA, matches this localization. MICA and the closely related MICE were recognized by intestinal epithelial T cells expressing diverse V(delta)1 gamma delta TCRs, These interactions involved the alpha 1 beta 2domains of MICA and MICE but were independent of antigen processing. With intestinal epithelial cell lines, the expression and recognition of MICA and MICE could be stress-induced. Thus, these molecules may broadly regulate protective responses by the V(delta)1 gamma delta T cells in the epithelium of the intestinal tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:11:57