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Titolo:
STRUCTURAL BASIS FOR A CA2-SENSING FUNCTION OF THE METABOTROPIC GLUTAMATE RECEPTORS()
Autore:
KUBO Y; MIYASHITA T; MURATA Y;
Indirizzi:
TOKYO METROPOLITAN INST NEUROSCI,DEPT NEUROPHYSIOL,MUSASHIDAI 2-6 TOKYO 1838526 JAPAN MEIJI COLL PHARM,DEPT MED PHYSIOL TOKYO 154003 JAPAN
Titolo Testata:
Science
fascicolo: 5357, volume: 279, anno: 1998,
pagine: 1722 - 1725
SICI:
0036-8075(1998)279:5357<1722:SBFACF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; MGLUR1 MUTANT MICE; MOLECULAR CHARACTERIZATION; SIGNAL-TRANSDUCTION; EXTRACELLULAR CALCIUM; SENSING RECEPTOR; EXPRESSION; CLONING; RAT; CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kubo et al., "STRUCTURAL BASIS FOR A CA2-SENSING FUNCTION OF THE METABOTROPIC GLUTAMATE RECEPTORS()", Science, 279(5357), 1998, pp. 1722-1725

Abstract

The metabotropic glutamate receptors (mGluRs) are widely distributed in the brain and play important roles in synaptic plasticity. Here it is shown that some types of mGluRs are activated not only by glutamatebut also by extracellular Ca2+(Ca-o(2+)). A single amino acid residuewas found to determine the sensitivity of mGluRs to Ca-o(2+). One of the receptors, mGluR1 alpha, but not its point mutant with reduced sensitivity to Ca-o(2+), caused morphological changes when transfected into mammalian cells, Thus, the sensing of Ca-o(2+) by mGluRs may be important in cells under physiological condition.

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Documento generato il 02/12/20 alle ore 15:36:29