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Titolo:
PREVALENCE AND PROGNOSTIC-SIGNIFICANCE OF EPILEPSY IN PATIENTS WITH GLIOMAS
Autore:
LOTE K; STENWIG AE; SKULLERUD K; HIRSCHBERG H;
Indirizzi:
NORWEGIAN RADIUM HOSP,DEPT ONCOL N-0310 OSLO NORWAY NORWEGIAN RADIUM HOSP,DEPT PATHOL N-0310 OSLO NORWAY UNIV OSLO,NATL HOSP,NEUROPATHOL LAB OSLO NORWAY UNIV OSLO,NATL HOSP,DEPT NEUROSURG OSLO NORWAY
Titolo Testata:
European journal of cancer
fascicolo: 1, volume: 34, anno: 1998,
pagine: 98 - 102
SICI:
0959-8049(1998)34:1<98:PAPOEI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRADE SUPRATENTORIAL ASTROCYTOMAS; CEREBRAL HEMISPHERES; RADIATION-THERAPY; INTRACEREBRAL TUMORS; MANAGEMENT; RADIOTHERAPY; ADULTS; OLIGODENDROGLIOMA; SURVIVAL; LIFE;
Keywords:
EPILEPSY; LOW-GRADE GLIOMA; HIGH-GRADE GLIOMA; PREVALENCE; AGE; PROGNOSTIC FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Lote et al., "PREVALENCE AND PROGNOSTIC-SIGNIFICANCE OF EPILEPSY IN PATIENTS WITH GLIOMAS", European journal of cancer, 34(1), 1998, pp. 98-102

Abstract

The aim of this study was to evaluate the prevalence and prognostic significance of epilepsy in 1028 patients diagnosed in the computer tomography (CT) era with histological low- or high-grade intracranial gliomas. Survival analysis included Kaplan-Meier plots, log-rank tests, logistic regression and Cox's analysis as implemented in the SPSS statistical package. Epilepsy was a positive univariate (P<0.0001) and multivariate, (P<0.03) prognostic factor for survival in the total patientgroup (n = 1028, relative risk of death 0.83, 95% confidence interval(CI) 0.70-0.98) as well as in the high-grade patient group (n = 649, relative risk of death 0.80, 95% CI 0.66-0.96), but not in the group of low-grade glioma patients (P > 0.2). The prevalence of epilepsy in glioblastoma patients was 251/512 (49%), 95/137 (69%) in anaplastic gliomas, and 322/379 (85%) in patients with low-grade gliomas, with 97 ofthe 102 T1 low-grade subgroup (95%) having epilepsy, indicating that the presence of epilepsy may select patients for early radiological diagnosis. The frequency of epilepsy at presentation decreased with age in high-grade glioma patients, and increased with age in low-grade glioma patients to a plateau in the fourth decade of Life (P<0.01). The prevalence of epilepsy in patients with histological intracranial gliomas varied with patient age and tumour histology, with low-grade patients having the highest prevalence. Epilepsy was a significant positive prognostic factor except in patients with low-grade gliomas, and may select low-grade patients for early diagnosis. (C) 1998 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:09:59