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Titolo:
A CAUSAL ROLE FOR E-CADHERIN IN THE TRANSITION FROM ADENOMA TO CARCINOMA
Autore:
PERL AK; WILGENBUS P; DAHL U; SEMB H; CHRISTOFORI G;
Indirizzi:
RES INST MOL PATHOL,DR BOHR GASSE 7 A-1030 VIENNA AUSTRIA RES INST MOL PATHOL A-1030 VIENNA AUSTRIA UMEA UNIV,DEPT MICROBIOL S-90187 UMEA SWEDEN
Titolo Testata:
Nature
fascicolo: 6672, volume: 392, anno: 1998,
pagine: 190 - 193
SICI:
0028-0836(1998)392:6672<190:ACRFEI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR LEF-1; BETA-CATENIN; PANCREATIC-ISLETS; GROWTH-FACTOR; EXPRESSION; TUMORIGENESIS; CELLS; PROGRESSION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Perl et al., "A CAUSAL ROLE FOR E-CADHERIN IN THE TRANSITION FROM ADENOMA TO CARCINOMA", Nature, 392(6672), 1998, pp. 190-193

Abstract

Development of malignant tumours is in part characterized by the ability of a tumour cell to overcome cell-cell adhesion and to invade surrounding tissue. E-cadherin is the main adhesion molecule of epithelia(1-3), and it has been implicated in carcinogenesis because it is frequently lost in human epithelial cancers(4-6). Re-establishing the functional cadherin complex in tumour cell lines results in a reversion from an invasive to a benign epithelial phenotype(7), However, it remained unresolved whether the loss of E-cadherin-mediated cell adhesion wasa cause or a consequence of tumour progression in vivo, Here we report that the loss of E-cadherin expression coincides with the transitionfrom well differentiated adenoma to invasive carcinoma in a transgenic mouse model of pancreatic beta-cell carcinogenesis (Rip1Tag2)(8). Intercrossing Rip1Tag2 mice with transgenic mice that maintain E-cadherin expression in beta-tumour cells results in arrest of tumour development at the adenoma stage, whereas expression of a dominant-negative form of E-cadherin induces early invasion and metastasis. The results demonstrate that loss of E-cadherin-mediated cell adhesion is one rate-limiting step in the progression from adenoma to carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:41:37