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Titolo:
ROLE OF THE NF-ATC TRANSCRIPTION FACTOR IN MORPHOGENESIS OF CARDIAC VALVES AND SEPTUM
Autore:
DELAPOMPA JL; TIMMERMAN LA; TAKIMOTO H; YOSHIDA H; ELIA AJ; SAMPER E; POTTER J; WAKEHAM A; MARENGERE L; LANGILLE BL; CRABTREE GR; MAK TW;
Indirizzi:
UNIV TORONTO,ONTARIO CANC INST,AMGEN INST,620 UNIV AVE TORONTO ON M5G2C1 CANADA UNIV TORONTO,ONTARIO CANC INST,AMGEN INST TORONTO ON M5G 2C1 CANADA UNIV TORONTO,DEPT MED BIOPHYS TORONTO ON M5G 2C1 CANADA UNIV TORONTO,DEPT IMMUNOL TORONTO ON M5G 2C1 CANADA STANFORD UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT DEV BIOL STANFORD CA 94305 UNIV TORONTO,DEPT PATHOL TORONTO ON M5S 1A8 CANADA TORONTO GEN DIV,MAX BELL RES CTR TORONTO ON M5G 2C4 CANADA
Titolo Testata:
Nature
fascicolo: 6672, volume: 392, anno: 1998,
pagine: 182 - 186
SICI:
0028-0836(1998)392:6672<182:ROTNTF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; CYCLOSPORINE-A; GENE; CALCINEURIN; FAMILY; IDENTIFICATION; CONTAINS; PROTEINS; MEMBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Delapompa et al., "ROLE OF THE NF-ATC TRANSCRIPTION FACTOR IN MORPHOGENESIS OF CARDIAC VALVES AND SEPTUM", Nature, 392(6672), 1998, pp. 182-186

Abstract

In lymphocytes, the expression of early immune response genes is regulated by NF-AT transcription factors(1,2) which translocate to the nucleus after dephosphorylation by the Ca2+-dependent phosphatase, calcineurin(3). We report here that mice bearing a disruption in the NF-ATc gene fail to develop normal cardiac valves and septa and die of circulatory failure before day 14.5 of development. NF-ATc is first expressed in the heart at day 7.5, and is restricted to the endocardium, a specialized endothelium that gives rise to the valves and septum. Within the endocardium, specific inductive events appear to activate NF-ATc: it is localized to the nucleus only in endocardial cells that are adjacent to the interface with the cardiac jelly and myocardium, which arethought to give the inductive stimulus to the valve primordia(4). Treatment of wild-type embryos with FK506, a specific calcineurin inhibitor(5), prevents nuclear localization of NF-ATc. These data indicate that the Ca2+/calcineurin/NF-ATc signalling pathway is essential for normal cardiac valve and septum morphogenesis; hence, NF-ATc and its regulatory pathways are candidates for genetic defects underlying congenital human heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 20:44:43