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Titolo:
ANTI-HIV ACTIVITY OF THE COMBINATION OF DIDANOSINE AND HYDROXYUREA INHIV-1-INFECTED INDIVIDUALS
Autore:
BIRON F; LUCHT F; PEYRAMOND D; FRESARD A; VALLET T; NUGIER F; GRANGE J; MALLEY S; HAMEDISANGSARI F; VILA J;
Indirizzi:
COMPAGNIE DEV AGUETTANT SA,BP 7144 F-69353 LYON 07 FRANCE COMPAGNIE DEV AGUETTANT SA F-69353 LYON 07 FRANCE HOP CROIX ROUSSE,SERV MALAD INFECT & TROP F-69317 LYON FRANCE HOP BELLEVUE,SERV MALAD INFECT & TROP ST ETIENNE FRANCE INSERM F-69008 LYON FRANCE
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
fascicolo: 1, volume: 10, anno: 1995,
pagine: 36 - 40
SICI:
1077-9450(1995)10:1<36:AAOTCO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTES; INFECTION; THERAPY;
Keywords:
HIV-1 INFECTION; DIDANOSINE; HYDROXYUREA; COMBINATION THERAPY;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
F. Biron et al., "ANTI-HIV ACTIVITY OF THE COMBINATION OF DIDANOSINE AND HYDROXYUREA INHIV-1-INFECTED INDIVIDUALS", Journal of acquired immune deficiency syndromes and human retrovirology, 10(1), 1995, pp. 36-40

Abstract

HIV is known to be present in massive amounts in both resting and actively replicating cells in infected individuals. We tested the combination of didanosine and hydroxyurea, known to suppress viral productionin vitro in both of these cell types, in a small number of asymptomatic patients. After 3 months of well tolerated treatment, we observed alarge reduction of viral load in the peripheral blood of all 12 patients, down to nonquantifiable levels in 7 of 12 as measured by infectious virus titer, and 6 of 12 as measured by plasma HIV-RNA. In this subgroup of 6 patients, whose baseline HIV-RNA was below 14,000 copies/ml, the median increase in CD4(+) count after 90 days of treatment was 244 cells/mm(3).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:00:08