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Titolo:
EXPRESSION OF ESTROGEN-RECEPTOR-BETA (ER-BETA) OCCURS IN MULTIPLE CELL-TYPES, INCLUDING SOME GERM-CELLS, IN THE RAT TESTIS
Autore:
SAUNDERS PTK; FISHER JS; SHARPE RM; MILLAR MR;
Indirizzi:
MRC,REPROD BIOL UNIT,37 CHALMERS ST EDINBURGH EH3 9EW MIDLOTHIAN SCOTLAND
Titolo Testata:
Journal of Endocrinology
fascicolo: 3, volume: 156, anno: 1998,
pagine: 13 - 17
SICI:
0022-0795(1998)156:3<13:EOE(OI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR; ANDROGEN RECEPTOR; SPERMATOGENESIS; LOCALIZATION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P.T.K. Saunders et al., "EXPRESSION OF ESTROGEN-RECEPTOR-BETA (ER-BETA) OCCURS IN MULTIPLE CELL-TYPES, INCLUDING SOME GERM-CELLS, IN THE RAT TESTIS", Journal of Endocrinology, 156(3), 1998, pp. 13-17

Abstract

The identification of a second oestrogen receptor (beta) has prompteda re-evaluation of the potential sites of action of oestrogens. The aim of the present study was to characterise immunoexpression of ER beta expression in the testis to complement earlier data which had demonstrated that expression of ER alpha is confined to testicular interstitial Leydig cells. In all testes studied, including those from both fetal (day 20.5 p.c.) and adult rats, ER beta was found to be expressed in multiple cell types. Sertoli cell nuclei were immunopositive at all ages. In adult testes expression in Sertoli cells was not stage dependent and was unaffected by ablation of Leydig cells. In fetal testes ERbeta was also expressed in peritubular cells, fetal Leydig cells and gonocytes. In the pubertal and adult testis ER beta was detected in the nuclei of spermatogonia and most pachytene spermatocytes. Weak immunopositive staining was present in the cytoplasm of spermatocytes undergoing the second meiotic division. In conclusion the widespread expression of ER beta in the testis is consistent with a role for oestrogensin modulating spermatogenesis, and hence fertility, in the male.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:56:49