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Titolo:
PLATELET GLYCOPROTEIN RECEPTOR IIIA POLYMORPHISM P1A2 AND ISCHEMIC STROKE RISK - THE STROKE PREVENTION IN YOUNG-WOMEN STUDY
Autore:
WAGNER KR; GILES WH; JOHNSON CJ; OU CY; BRAY PF; GOLDSCHMIDTCLERMONT PJ; CROFT JB; BROWN VK; STERN BJ; FEESER BR; BUCHHOLZ DW; EARLEY CJ; MACKO RF; MCCARTER RJ; SLOAN MA; STOLLEY PD; WITYK RJ; WOZNIAK MA; PRICE TR; KITTNER SJ;
Indirizzi:
UNIV MARYLAND,DEPT NEUROL,BRESSLER BLDG,ROOM 12-013,655 W BALTIMORE ST BALTIMORE MD 21201 UNIV MARYLAND,DEPT NEUROL BALTIMORE MD 21201 UNIV MARYLAND,DEPT EPIDEMIOL & PREVENT MED BALTIMORE MD 21201 JOHNS HOPKINS UNIV,DEPT NEUROL BALTIMORE MD 21218 JOHNS HOPKINS UNIV,DEPT MED BALTIMORE MD 00000 CTR DIS CONTROL & PREVENT,CARDIOVASC HLTH BRANCH,NATL CTR CHRON DIS PREVENT & HLTH PROMOT ATLANTA GA 00000 CTR DIS CONTROL & PREVENT,NATL CTR ENVIRONM HLTH,DIV ENVIRONM HLTH LAB SCI ATLANTA GA 00000 EMORY UNIV,DEPT NEUROL ATLANTA GA 30322
Titolo Testata:
Stroke
fascicolo: 3, volume: 29, anno: 1998,
pagine: 581 - 585
SICI:
0039-2499(1998)29:3<581:PGRIPP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEN; ALLOANTIGENS; THROMBOSIS; DISEASE; COMPLEX;
Keywords:
CEREBROVASCULAR DISORDERS; PLATELETS; POLYMORPHISM (GENETICS); YOUNG ADULTS; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Wagner et al., "PLATELET GLYCOPROTEIN RECEPTOR IIIA POLYMORPHISM P1A2 AND ISCHEMIC STROKE RISK - THE STROKE PREVENTION IN YOUNG-WOMEN STUDY", Stroke, 29(3), 1998, pp. 581-585

Abstract

Background and Purpose-Platelet glycoprotein IIb/IIIa (GpIIb-IIIa), amembrane receptor for fibrinogen and von Willebrand factor, has been implicated in the pathogenesis of acute coronary syndromes but has notbeen previously investigated in relation to stroke in young adults. Methods-We used a population-based case-control design to examine the association of the GpIIIa polymorphism P1A2 with stroke in young women. Subjects were 65 cerebral infarction cases (18 patients with and 47 without an identified probable etiology) 15 to 44 years of age from theBaltimore-Washington region and 122 controls frequency matched by agefrom the same geographic area. A face-to-face interview for vascular disease risk factors and a blood sample for the P1A2 allele and serum cholesterol were obtained from each participant. Logistic regression was used to estimate the odds ratio for one or more P1A2 alleles after adjustment for other risk factors. Results-Among cases and controls, the prevalence rates of one or more P1A2 alleles were 21% and 22% amongblacks and 36% and 28% among whites, respectively. This genotype was significantly associated with hypertension only in black control subjects but otherwise not with any of the established vascular risk factors. The adjusted odds ratio for cerebral infarction of one or more P1A2alleles was 1.1 (confidence interval [CI], 0.6 to 2.3) overall, 0.5 (CI, 0.1 to 7.1) among blacks, and 1.4 (CI, 0.5 to 3.7) among whites. For the cases with an identified probable etiology, the corresponding odds ratios were 3.0 (CI, 0.9 to 10.4) overall, 0.7 (CI, 0.1 to 7.1) among blacks, and 12.8 (CI, 1.2 to 135.0) among whites. Conclusions-No association was found between the P1A2 polymorphism of GpIIIa and youngwomen with stroke. However, subgroup analyses showed that the P1A2 polymorphism of GpIIIa appeared to be associated with stroke risk among white women, particularly those with a clinically identified probable etiology for their stroke. Further work with an emphasis on stroke subtypes and with multiracial populations is warranted.

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Documento generato il 05/07/20 alle ore 13:20:12