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Titolo:
RISK OF STROKE IN YOUNG-WOMEN AND 2 PROTHROMBOTIC MUTATIONS - FACTOR-V-LEIDEN AND PROTHROMBIN GENE VARIANT (G20210A)
Autore:
LONGSTRETH WT; ROSENDAAL FR; SISCOVICK DS; VOS HL; SCHWARTZ SM; PSATY BM; RAGHUNATHAN TE; KOEPSELL TD; REITSMA PH;
Indirizzi:
UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT NEUROL,BOX 359775,325 9TH AVESEATTLE WA 98104 UNIV WASHINGTON,CARDIOVASC HLTH RES UNIT SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV LEIDEN HOSP,HEMOSTASIS & THROMBOSIS RES CTR NL-2300 RC LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT CLIN EPIDEMIOL NL-2300 RC LEIDEN NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,LAB EXPT INTERNAL MED NL-1012 WX AMSTERDAM NETHERLANDS
Titolo Testata:
Stroke
fascicolo: 3, volume: 29, anno: 1998,
pagine: 577 - 580
SICI:
0039-2499(1998)29:3<577:ROSIYA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-C; CEREBRAL VENOUS THROMBOSIS; POOR ANTICOAGULANT RESPONSE; COAGULATION-FACTOR-V; ISCHEMIC STROKE; CEREBROVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ARTERIAL THROMBOSIS; RESISTANCE; CHILDHOOD;
Keywords:
CEREBROVASCULAR DISORDERS; MUTATION; FACTOR V; PROTHROMBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
W.T. Longstreth et al., "RISK OF STROKE IN YOUNG-WOMEN AND 2 PROTHROMBOTIC MUTATIONS - FACTOR-V-LEIDEN AND PROTHROMBIN GENE VARIANT (G20210A)", Stroke, 29(3), 1998, pp. 577-580

Abstract

Background and Purpose-Factor V Leiden and a prothrombin gene variant, G20210A, are mutations associated with a thrombotic risk. The aim ofour study was to assess whether these mutations increase the risk of stroke in women under 45 years of age. Methods-We conducted a case-control study in western Washington state. Case patients were women aged 18 to 44 years with a first stroke (n=106). Control subjects were women without stroke recruited from the same region by use of random-digittelephone dialing (n=391). All were interviewed and provided blood specimens, which were genotyped for these mutations. Results-Factor V Leiden was found in 0.9% of case patients, a single patient with a subarachnoid hemorrhage, and in 4.1% of control subjects. The odds ratio (OR) for any stroke was 0.2 (95% confidence interval [CI], 0.03 to 1.7). The prothrombin variant was found in 1.9% of case patients, 1 with a venous stroke and I with an ischemic stroke, and in 1.6% of control subjects. The OR for any stroke was 1.48 (95% CI, 0.14 to 9.17). ORs forstroke types were also not statistically significant. Conclusions-In this study, neither factor V Leiden nor the prothrombin variant (G20210A) was an important risk factor for stroke in young women. In this setting, screening for these mutations cannot be recommended. Unansweredby this study is whether screening would be useful in select patients, such as those with a strong family history of thrombophilia or thosewith venous strokes.

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Documento generato il 03/12/20 alle ore 05:44:21