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Titolo:
EVALUATION OF A CANDIDATE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)VACCINE IN MACAQUES - EFFECT OF VACCINATION WITH HIV-1 GP120 ON SUBSEQUENT CHALLENGE WITH HETEROLOGOUS SIMIAN IMMUNODEFICIENCY VIRUS-HIV-1 CHIMERIC VIRUS
Autore:
STOTT EJ; ALMOND N; KENT K; WALKER B; HULL R; ROSE J; SILVERA P; SANGSTER R; CORCORAN T; LINES J; SILVERA K; LUCIW P; MURPHYCORB M; MOMIN P; BRUCK C;
Indirizzi:
NATL INST BIOL STAND & CONTROLS,BLANCHE LANE S MIMMS POTTERS BAR EN6 3QG HERTS ENGLAND UNIV CALIF DAVIS,DEPT MED PATHOL,SCH MED DAVIS CA 95616 TULANE UNIV,DELTA REG PRIMATE RES CTR COVINGTON LA 70433 SMITHKLINE BEECHAM BIOL B-1330 RIXENSART BELGIUM
Titolo Testata:
Journal of General Virology
, volume: 79, anno: 1998,
parte:, 3
pagine: 423 - 432
SICI:
0022-1317(1998)79:<423:EOACHT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL; CYNOMOLGUS MACAQUES; SIV INFECTION; ENVELOPE GLYCOPROTEIN; ENV RECOMBINANTS; RHESUS MACAQUES; IN-VIVO; PROTECTION; CHIMPANZEES; IMMUNIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Stott et al., "EVALUATION OF A CANDIDATE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)VACCINE IN MACAQUES - EFFECT OF VACCINATION WITH HIV-1 GP120 ON SUBSEQUENT CHALLENGE WITH HETEROLOGOUS SIMIAN IMMUNODEFICIENCY VIRUS-HIV-1 CHIMERIC VIRUS", Journal of General Virology, 79, 1998, pp. 423-432

Abstract

Human immunodeficiency virus type 1 (HIV-1) envelope vaccines can nowbe evaluated for efficacy in macaques by challenging with chimeric viruses in which the env, tot and rev genes of simian immunodeficiency virus (SIV) have been replaced by those of HIV-1, Most experiments haveso far been conducted using gp120 molecules derived from T-cell-adapted LAI or MN strains of HIV-1, which predominantly use the CXCR-4 co-receptor. These vaccines protect against infection by apathogenic chimeric virus carrying the same envelope sequences, In the experiment described here, four macaques were vaccinated with W61D gp120 derived froma low passage Dutch isolate and capable of inhibiting the binding of MIP1 beta to the co-receptor CCR-5, This vaccine was potent, inducing high titres of binding and neutralizing antibodies against the homologous HIV-1 and tenfold lower titres against a heterologous challenge virus (SHIVSF33) in which the env, tot and rev genes of SIV had been replaced by those of a San Francisco isolate, HIV-1(SF33). Despite strongimmune responses to the vaccine there was no evidence that it protected against challenge with this chimeric virus, The antigenic divergence between vaccine and challenge virus or the increased virulence of the challenge virus may be responsible for the inability of this vaccineto protect against infection by SHIVSF33.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:50:02