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Titolo:
EFFECTS OF VARIOUS FACTORS INCLUDING THE CYP2D6 GENOTYPE AND COADMINISTRATION OF FLUNITRAZEPAM ON THE STEADY-STATE PLASMA-CONCENTRATIONS OFBROMPERIDOL AND ITS REDUCED METABOLITE
Autore:
SUZUKI A; OTANI K; MIHARA K; YASUI N; KONDO T; TOKINAGA N; FURUKORI H; KANEKO S; INOUE Y; HAYASHI K;
Indirizzi:
HIROSAKI UNIV,SCH MED,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV,SCH MED,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN YAMAGATA UNIV,SCH MED,DEPT NEUROPSYCHIAT YAMAGATA 99023 JAPAN YOSHITOMI PHARMACEUT IND LTD,PHARMACEUT TECHNOL CTR FUKUOKA 871 JAPAN GUNMA UNIV,SCH HLTH SCI,DEPT ALLIED MED SCI MAEBASHI GUMMA 371 JAPAN
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 135, anno: 1998,
pagine: 333 - 337
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE HYDROXYLATION; POOR METABOLIZERS; CIGARETTE-SMOKING; GENETIC-ANALYSIS; SPARTEINE; PHENOTYPE; HALOPERIDOL; POPULATION; OXIDATION; DELETION;
Keywords:
BROMPERIDOL; REDUCED BROMPERIDOL; PLASMA CONCENTRATION; METABOLISM; CYP2D6 GENOTYPE; FLUNITRAZEPAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Suzuki et al., "EFFECTS OF VARIOUS FACTORS INCLUDING THE CYP2D6 GENOTYPE AND COADMINISTRATION OF FLUNITRAZEPAM ON THE STEADY-STATE PLASMA-CONCENTRATIONS OFBROMPERIDOL AND ITS REDUCED METABOLITE", Psychopharmacology, 135(4), 1998, pp. 333-337

Abstract

The effects of various factors, including the cytochrome P450 (CYP) 2D6 genotype and the coadministration of flunitrazepam, on the steady-state plasma concentrations (Css) of bromperidol and its reduced metabolite were studied in 62 schizophrenic inpatients receiving bromperidol12 mg/day. By use of allele-specific PCR analysis, the wild type allele (CYP2D61A) and four mutated alleles causing either absent (CYP2D6*3, CYP2D64 and CYP2D6*5) or decreased (CYP2D6*10) CYP2D6 activity were identified. The means (ranges) of the Css of bromperidol and reducedbromperidol corrected to the median body weight were 7.2 (1.3-17.4) and 2.2 (0.4-8.9) ng/ml, respectively. Neither the Css of bromperidol nor that of reduced bromperidol significantly differed among the patients with no (n = 28), one (n = 30) and two mutated alleles (n = 4). Thepatients coadministered with flunitrazepam (n = 52) had significantly(P < 0.05) higher Css of bromperidol, but not reduced bromperidol, than those not (n = 10). Age, sex and smoking had no significant effectson the Css of these compounds. The present study thus suggests that the polymorphic CYP2D6 is not involved in the metabolism of bromperidoland reduced bromperidol to a major extent. The coadministration of flunitrazepam inhibits the metabolism of bromperidol, but age, sex and smoking do not affect it.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:48:20