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Titolo:
PROLACTIN RESPONSE TO BROMPERIDOL TREATMENT IN SCHIZOPHRENIC-PATIENTS
Autore:
YASUI N; KONDO T; OTANI K; ISHIDA M; MIHARA K; SUZUKI A; KANEKO S; INOUE Y;
Indirizzi:
HIROSAKI UNIV HOSP,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV HOSP,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN YAMAGATA UNIV,SCH MED,DEPT NEUROPSYCHIAT YAMAGATA 99023 JAPAN YOSHITOMI PHARMACEUT IND LTD,PHARMACEUT TECHNOL CTR FUKUOKA JAPAN
Titolo Testata:
Pharmacology & toxicology
fascicolo: 3, volume: 82, anno: 1998,
pagine: 153 - 156
SICI:
0901-9928(1998)82:3<153:PRTBTI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-RESPONSE; HALOPERIDOL; SERUM; ZOTEPINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
N. Yasui et al., "PROLACTIN RESPONSE TO BROMPERIDOL TREATMENT IN SCHIZOPHRENIC-PATIENTS", Pharmacology & toxicology, 82(3), 1998, pp. 153-156

Abstract

The prolactin response to an antipsychotic drug, bromperidol was studied in 24 schizophrenic in-patients (13 males, 11 females). Eight patients were given 6 mg/day, 8 were given 12 mg/day and 8 were given 18 mg/day. Duration of treatment was 3 weeks. Plasma concentrations of bromperidol and reduced bromperidol were measured by high-performance liquid chromatography, and that of prolactin was measured by radioimmunoassay. Bromperidol treatment significantly (P<0.01) increased plasma concentration of prolactin each week. The mean+/-S.D. of the Delta-prolactin (the mean concentration during treatment minus the pretreatment concentration) was 13.3+/-12.4 ng/ml. Multiple regression analysis showed that the Delta-prolactin concentration was significantly greater infemales than in males (P<0.05) and correlated to plasma concentrations of bromperidol (P<0.001) and reduced bromperidol (P<0.0001). These results suggest that the prolactin response to bromperidol treatment depend on plasma concentrations of both bromperidol and reduced bromperidol and gender, and that reduced bromperidol is involved in the pharmacological effects during bromperidol treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:59:15