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Titolo:
A MINIMALLY REPLICATIVE HIV-2 LIVE-VIRUS VACCINE PROTECTS MACACA-NEMESTRINA FROM DISEASE AFTER HIV-2(287) CHALLENGE
Autore:
LOONEY DJ; MCCLURE J; KENT SJ; RADAELLI A; KRAUS G; SCHMIDT A; STEFFY K; GREENBERG P; HU SL; MORTON WR; WONGSTAAL F;
Indirizzi:
VA MED CTR SAN DIEGO,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 VA SAN DIEGO HEALTHCARE SYST SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,DEPT MED 0678 LA JOLLA CA 92093 UNIV MILAN,DEPT PHARMACOL,INST PHARMACOL SCI I-20129 MILAN ITALY BRISTOL MYERS SQUIBB CO,PHARMACEUT RES INST SEATTLE WA 98121 UNIV WASHINGTON,HLTH SCI CTR,REG PRIMATE RES CTR SEATTLE WA 98195
Titolo Testata:
Virology
fascicolo: 1, volume: 242, anno: 1998,
pagine: 150 - 160
SICI:
0042-6822(1998)242:1<150:AMRHLV>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMIAN IMMUNODEFICIENCY VIRUS; THYMIDINE KINASE GENE; RHESUS MACAQUES; SUBUNIT VACCINES; ATTENUATED SIV; BLOOD-CELLS; T-CELLS; INFECTION; IMMUNIZATION; MONKEYS;
Keywords:
HIV-2; VACCINE; ANIMAL MODELS; VIROLOGY QUANTITATIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Looney et al., "A MINIMALLY REPLICATIVE HIV-2 LIVE-VIRUS VACCINE PROTECTS MACACA-NEMESTRINA FROM DISEASE AFTER HIV-2(287) CHALLENGE", Virology, 242(1), 1998, pp. 150-160

Abstract

M. nemestrina immunized with an apathogenic HIV-2 molecular clone (HIV-2(KR)) were protected from CD4 decline and disease upon challenge with HIV-2(287), after any immunizing virus could be detected. Higher but not lower inocula of HIV-2(KR) were protective against intravenous inoculation of either 10(5) or 10(1) TCID50 of HIV-2(287). Protected animals displayed substantial reductions in PBMC proviral burden (1-3 logs), viral titers (1-2 logs), and plasma viral RNA (2-4 logs) comparedto unprotected or naive animals as early as 1 week postinfection. Plasma viral RNA became undetectable after 24 weeks in protected animals,but remained high in unprotected animals, No viral RNA was present inthe spleen of the protected animal necropsied more than a year after challenge (though viral DNA was still present). No neutralizing responses could be demonstrated, but CTL activity was detected sooner and athigher levels after challenge in protected than in unprotected macaques. In this novel HIV-2 vaccine model, protection was clearly dose-dependent, and clearance of challenge virus RNA from the plasma did not require detectable ongoing replication of the immunizing virus at the time of challenge, (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:20:23