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Titolo:
INTERLEUKIN-1-BETA ADMINISTERED INTRACEREBROVENTRICULARLY STIMULATES THE RELEASE OF NORADRENALINE IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS VIA PROSTAGLANDIN IN THE RAT
Autore:
TSUMORI C; SHIBASAKI T; HOTTA M; TAKEUCHI K; YAMAUCHI N; IMAKI T; WAKABAYASHI I; DEMURA H;
Indirizzi:
NIPPON MED COLL,DEPT PHYSIOL,BUNKYO KU,1-1-5 SENDAGI TOKYO 1138602 JAPAN NIPPON MED COLL,DEPT PHYSIOL,BUNKYO KU TOKYO 1138602 JAPAN NIPPON MED COLL,DEPT MED,BUNKYO KU TOKYO 1138602 JAPAN TOKYO WOMENS MED COLL,INST CLIN ENDOCRINOL,DEPT MED TOKYO 1628666 JAPAN
Titolo Testata:
Endocrine journal
fascicolo: 1, volume: 45, anno: 1998,
pagine: 127 - 130
SICI:
0918-8959(1998)45:1<127:IAIST>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECRETION; HORMONE; INVOLVEMENT; INJECTION; INVITRO; SYSTEM; STRESS; SITES; FEVER; ACTH;
Keywords:
NORADRENALINE; PARAVENTRICULAR NUCLEUS; MICRODIALYSIS; INTERLEUKIN; PROSTAGLANDIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Tsumori et al., "INTERLEUKIN-1-BETA ADMINISTERED INTRACEREBROVENTRICULARLY STIMULATES THE RELEASE OF NORADRENALINE IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS VIA PROSTAGLANDIN IN THE RAT", Endocrine journal, 45(1), 1998, pp. 127-130

Abstract

We evaluated the effect of intracerebroventricular (icv) administration of interleukin (icv)-1 beta on the rectal temperature and the release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN) of the rat. IL-1 beta increased rectal temperature at doses ranging from 300 pg to 300 ng, whereas it, at doses ranging from 3 ng to 300 ng, significantly stimulated the release of NA in the PVN measured by intracerebral microdialysis. The stimulatory effect of IL-1 beta on the release of NA was blocked by the subcutaneous injection of indomethacin. These findings suggest that IL-1 beta stimulates the release ofNA in the PVN via prostaglandin, and that the release of NA in the PVN is not necessarily related to the increase in body temperature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:07:52