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Titolo:
EFFECT OF THE H-1 BLOCKER D-CHLORPHENIRAMINE ON CEREBRAL BLOOD-FLOW IN THE CONSCIOUS DOG DURING NORMOCAPNIC HYPOXIA
Autore:
AUDIBERT G; SIAT J; MULLER C; HARTEMANN D; NAJA G; SAUNIER CG;
Indirizzi:
HOP CENT,DEPT ANESTHESIOL REANIMAT CHIRURG,29 AVE MARECHAL DE LATTRE DE TASSIGNY,CO 34 F-54035 NANCY FRANCE CHU BRABOIS,SERV CHIRURG VASC VANDOEUVRE NANCY FRANCE UNIV NANCY 1,INSERM,U14 F-54506 VANDOEUVRE NANCY FRANCE
Titolo Testata:
Clinical physiology
fascicolo: 1, volume: 18, anno: 1998,
pagine: 27 - 33
SICI:
0144-5979(1998)18:1<27:EOTHBD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIES INVITRO; HISTAMINE-RECEPTORS; ENDOTHELIUM; BRAIN; RAT;
Keywords:
H-1 RECEPTOR BLOCKER; HISTAMINE; HYPOXIA; RADIOLABELED MICROSPHERES; REGIONAL CEREBRAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G. Audibert et al., "EFFECT OF THE H-1 BLOCKER D-CHLORPHENIRAMINE ON CEREBRAL BLOOD-FLOW IN THE CONSCIOUS DOG DURING NORMOCAPNIC HYPOXIA", Clinical physiology, 18(1), 1998, pp. 27-33

Abstract

The mechanism causing cerebral vasodilatation during hypoxia remains unclear. A role for histamine is suspected because H-2 receptor-blocking drugs blunt the hypoxia-induced increase in cerebral blood flow (CBF). Moreover, in vitro blockade of H-1 receptors by chlorpheniramine decreases the vasodilatation of cerebral arteries that is induced by histamine. The present study tested the hypothesis that an H-1 receptor blocker (d-chlorpheniramine) would have a similar effect in vivo during hypoxia. Isocapnic hypoxia (inspired oxygen fraction, FIO2 = 0.10; inspired carbon dioxide fraction, FICO2 = 0.035) was induced in 16 conscious dogs randomly divided into two groups: eight dogs received saline intravenously (controls) at time 0 (normoxia) and after 2 h and 4 h hypoxia, and the other eight dogs received d-chlorpheniramine intravenously (0.5 mg kg(-1)) to block the H-1 receptors. Regional CBF was measured by the radioactive microspheres technique 15 min after each injection of d-chlorpheniramine or saline. In the control group, CBF increased during hypoxia in all regions of the brain. In the d-chlorpheniramine group, total CBF increased similarly after 2 h of hypoxia. After 4 h of hypoxia, the increase was limited, especially in the pens, cerebral peduncles, hippocampus, hypothalamus, thalamus, and occipital lobes (six out of 12 studied regions). It is concluded that the H-1 blocker d-chlorpheniramine did not strongly inhibit the increase in CBF during hypoxia. After cumulative doses, however, as in the fourth hour ofhypoxia, the increase in total CBF was limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 03:56:24