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Titolo:
ZINC DEPLETION SUPPRESSES TUMOR-GROWTH IN MICE
Autore:
TAKEDA A; GOTO K; OKADA S;
Indirizzi:
UNIV SHIZUOKA,SCH PHARMACEUT SCI,DEPT RADIOBIOCHEM,52-1 YADA SHIZUOKA422 JAPAN
Titolo Testata:
Biological trace element research
fascicolo: 1-3, volume: 59, anno: 1997,
pagine: 23 - 29
SICI:
0163-4984(1997)59:1-3<23:ZDSTIM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC METALLOTHIONEIN; ASCITES TUMOR; DEFICIENCY; INDUCTION; INHIBITION; ELEVATION; COPPER; RAT;
Keywords:
CADMIUM CHLORIDE; CADMIUM-ZINC METALLOTHIONEIN; TUMOR GROWTH; ZINC METALLOTHIONEIN; ZINC RESTRICTION; ZINC UPTAKE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Takeda et al., "ZINC DEPLETION SUPPRESSES TUMOR-GROWTH IN MICE", Biological trace element research, 59(1-3), 1997, pp. 23-29

Abstract

The hypothesis that in tumor-bearing animals an increase of host hepatic zinc metallothionein (Zn-MT) causes a restriction of zinc in the tumor tissue was studied. Three types of tumors were induced in laboratory mice by cell transplant. Tumor growth appears to be inhibited under zinc-deficient conditions, even in cases where zinc deficiency was started after tumor cell transplant. The survival times of tumor-bearing mice were prolonged by administration of cadmium chloride, which induces the synthesis of a combined zinc-cadmium metallothionein derivative in the host Liver, but not in the tumor tissue, leading to an increase of hepatic zinc in the treated animals. The uptake of Zn-65 by theliver of Cd-treated, tumor bearing mice was significantly higher thanthat of controls whereas uptake of Zn-65 by tumor cells was significantly higher in controls than in the treated animals. These results suggest that restriction of zinc intake suppresses tumor growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:26:41