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Titolo:
ASTROCYTES ARE THE MAJOR SOURCE OF NERVE GROWTH-FACTOR UP-REGULATION FOLLOWING TRAUMATIC BRAIN INJURY IN THE RAT
Autore:
GOSS JR; OMALLEY ME; ZOU LL; STYREN SD; KOCHANEK PM; DEKOSKY ST;
Indirizzi:
UNIV PITTSBURGH,MED CTR,DEPT PSYCHIAT PITTSBURGH PA 15213 UNIV PITTSBURGH,MED CTR,DEPT NEUROBIOL PITTSBURGH PA 15213 UNIV PITTSBURGH,MED CTR,DEPT ANESTHESIOL PITTSBURGH PA 15213 UNIV PITTSBURGH,MED CTR,DEPT NEUROL,WESTERN PSYCHIAT INST & CLIN PITTSBURGH PA 15213 UNIV PITTSBURGH,MED CTR,SAFAR CTR RESUSCITAT RES PITTSBURGH PA 15213
Titolo Testata:
Experimental neurology
fascicolo: 2, volume: 149, anno: 1998,
pagine: 301 - 309
SICI:
0014-4886(1998)149:2<301:AATMSO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR MESSENGER-RNA; PHYSIOLOGICAL STOP PATHWAY; KAINIC ACID INJECTION; C-FOS; NEUROTROPHIC FACTOR; LIMBIC SEIZURES; FACTOR GENE; DIFFERENTIAL REGULATION; AXONAL REGENERATION; CORTICAL ASTROCYTES;
Keywords:
ASTROCYTE; HIPPOCAMPUS; HYPOTHERMIA; IN SITU HYBRIDIZATION; NERVE GROWTH FACTOR; TRAUMATIC BRAIN INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Goss et al., "ASTROCYTES ARE THE MAJOR SOURCE OF NERVE GROWTH-FACTOR UP-REGULATION FOLLOWING TRAUMATIC BRAIN INJURY IN THE RAT", Experimental neurology, 149(2), 1998, pp. 301-309

Abstract

Previous studies from our group have demonstrated an upregulation in nerve growth factor (NGF) RNA and protein in the cortex 24 h followingtraumatic brain injury (TBI) in a rat model. This increase in NGF is suppressed if rats are subjected to 4 h of whole-body hypothermia following TBI. In the present study we used in situ hybridization to extend our initial RNA gel-blot (Northern) hybridization findings by demonstrating that NGF RNA is increased in the cortex following TBI and thathypothermia diminishes this response. Further, by combining in situ hybridization with immunocytochemistry for glial fibrillary acidic protein we demonstrate that astrocytes are the major cellular source for the upregulation in NGF and that this upregulation can be observed in the hippocampus as early as 3 h posttrauma. The predominantly astrocytic origin suggests that the NGF upregulation is not related primarily to cholinotrophic activities. We hypothesize that its function is to stimulate upregulation of antioxidant enzymes, as part of an injury-induced cascade, and that supplementation of NGF or antioxidants may be warranted in hypothermic therapies for head injury. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:49:57