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Titolo:
CEREBROSPINAL-FLUID MONONUCLEAR CELL COUNTS INFLUENCE CSF HIV-1 RNA LEVELS
Autore:
MARTIN C; ALBERT J; HANSSON P; PEHRSSON PO; LINK H; SONNERBORG A;
Indirizzi:
HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT NEUROL S-14186 HUDDINGE SWEDEN KAROLINSKA INST,SWEDISH INST INFECT DIS CONTROL,DEPT CLIN VIROL S-10401 STOCKHOLM SWEDEN KAROLINSKA HOSP,KAROLINSKA INST,DEPT REHABIL MED,NEUROGEN PAIN UNIT STOCKHOLM SWEDEN HUDDINGE UNIV HOSP,KAROLINSKA INST,DIV INFECT DIS STOCKHOLM SWEDEN HUDDINGE UNIV HOSP,KAROLINSKA INST,DIV CLIN VIROL STOCKHOLM SWEDEN
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
fascicolo: 3, volume: 17, anno: 1998,
pagine: 214 - 219
SICI:
1077-9450(1998)17:3<214:CMCCIC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; AIDS DEMENTIA COMPLEX; TYPE-1 V3 SEQUENCES; SEROPOSITIVE INDIVIDUALS; NEUROLOGIC ABNORMALITIES; VIROLOGICAL MARKERS; DISEASE; AMPLIFICATION; SYMPTOMS;
Keywords:
HIV-1; REVERSE TRANSCRIPTION; POLYMERASE CHAIN REACTION; CEREBROSPINAL FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
C. Martin et al., "CEREBROSPINAL-FLUID MONONUCLEAR CELL COUNTS INFLUENCE CSF HIV-1 RNA LEVELS", Journal of acquired immune deficiency syndromes and human retrovirology, 17(3), 1998, pp. 214-219

Abstract

This study evaluated the relation between cerebrospinal fluid (CSF) mononuclear cells (MNC) and CSF HIV-1 RNA levels. HIV-1 RNA levels in plasma and CSF were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) in 58 consecutive patients with neurologic symptoms and late HIV-1 Infection. The majority of the patients had no central nervous system (CNS) complication (n = 36), 11 had AIDS dementia complex (ADC) and 11 had CNS opportunistic infection (CNS OI). CSF cell counts were analyzed using a method that also evaluated hypocellular CSF (i.e., from 0.1 x 10(6) cells/L). A strong correlation was found between CSF MNC and CD4+ lymphocyte counts in blood (r = 0.58; p < .0001). HIV-1 RNA was detected in all plasma samples and in 38 of 58 (66%) of the cell-free CSF samples. CSF HIV-1 RNA was less frequently detected in patients with hypocellular CSF than in patients with normocellular or pleocytic CSF (13 of 28 patients [46%] versus 10 of 14 patients [71%] versus 15 of 16 patients [94%] respectively). The levels of CSF HIV-1 RNA correlated with the CSF MNC count (r = 0.61; p < .0001). The correlation also remained strong within the clinical subgroups of CNS asymptomatic patients (r = 0.55;p < .001) and ADC patients (r = 0.79; p <.001), but not among CNS OI patients (r = 0,19). Patients with CNS OIwere found to have higher CSF HIV-1 RNA levels than the patients without evidence of CNS complication. Thus, a close relation was found between CSF HIV-1 RNA levels and CSF MNC counts. These data support the hypothesis that a substantial part of the virus in the CSF of HIV-1-infected patients is locally produced by CSF MNC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:58:12