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Titolo:
ASSESSMENT OF DIAGNOSTIC PERFORMANCE OF QUANTITATIVE FLOW MEASUREMENTS IN NORMAL SUBJECTS AND PATIENTS WITH ANGIOGRAPHICALLY DOCUMENTED CORONARY-ARTERY DISEASE BY MEANS OF N-13 AMMONIA AND POSITRON-EMISSION-TOMOGRAPHY
Autore:
MUZIK O; DUVERNOY C; BEANLANDS RSB; SAWADA S; DAYANIKLI F; WOLFE ER; SCHWAIGER M;
Indirizzi:
CHILDRENS HOSP MICHIGAN,POSITRON EMISS TOMOG CTR,3901 BEAUBIEN BLVD DETROIT MI 48201 UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV NUCL MED ANN ARBOR MI 48109
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 3, volume: 31, anno: 1998,
pagine: 534 - 540
SICI:
0735-1097(1998)31:3<534:AODPOQ>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; N-13 AMMONIA; QUANTIFICATION; PET; RESERVE; VALIDATION; PERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
O. Muzik et al., "ASSESSMENT OF DIAGNOSTIC PERFORMANCE OF QUANTITATIVE FLOW MEASUREMENTS IN NORMAL SUBJECTS AND PATIENTS WITH ANGIOGRAPHICALLY DOCUMENTED CORONARY-ARTERY DISEASE BY MEANS OF N-13 AMMONIA AND POSITRON-EMISSION-TOMOGRAPHY", Journal of the American College of Cardiology, 31(3), 1998, pp. 534-540

Abstract

Objectives. Regional myocardial blood how (MDF) and flow reserve measurements using nitrogen-13 (N-13) ammonia positron emission tomography(PET) were compared with quantitative coronary angiography to determine their utility in the detection of significant coronary artery disease (CAD). Background. Dynamic PET protocols using N-13 ammonia allow regional quantification of MBE and flow reserve. To establish the diagnostic performance of this method, the sensitivity and specificity mustbe known for varying decision thresholds. Methods. MBF and flow reserve for three coronary territories were determined in 20 normal subjects and 31 patients with angiographically documented CBD by means of dynamic PET and a three-compartment model far N-13 ammonia kinetics. Ten normal subjects defined the normal mean and SD of MBF and flow reserve, and 10 normal subjects were compared with patients. PET flow obtained in the territory with the most severe stenosis in each patient mas correlated with the angiographic assessment of the stenosis (severity greater than or equal to 50%, greater than or equal to 70%, greater than or equal to 90%). Receiver operating characteristic (ROC) curve analysis was performed for 1.5, 2.01 2.5, 3.0 and 4.0 SD of how abnormalities. Results. MBF and flow reserve values from the normal subjects andfrom territories with documented stenoses greater than or equal to 50% were significantly different (p < 0.051). A significant difference was found between normal subjects and angiographically normal territories of patients with CAD, High diagnostic accuracy and sensitivity, with moderately high specificity, were demonstrated for detection of all stenoses. Conclusions. Quantification of myocardial perfusion using dynamic PET and N-13 ammonia provides a high performance level for the detection and localization of CAD). The specificity of dynamic PET was excellent in patients with a low likelihood of CAD, whereas an abnormal flow reserve in angiographically normal territories was postulated to represent early functional abnormalities of vascular reactivity. (C)1998 by the American College of Cardiology.

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Documento generato il 27/01/20 alle ore 08:04:31